Technology Process of Benzoic acid, 4-hydroxy-2-methoxy-6-(2-oxoheptyl)-, methyl ester
There total 12 articles about Benzoic acid, 4-hydroxy-2-methoxy-6-(2-oxoheptyl)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 3h;
balloon pressure;
DOI:10.1021/ol047507p
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 75 percent / triphenylphosphine; DIAD / tetrahydrofuran / 2 h / 0 - 20 °C
2: 94 percent / pyridine / CH2Cl2 / 1.5 h / 20 °C
3: 80 percent / tBuNH2 / PdCl2(dppf)*CH2Cl2 / propan-2-ol; H2O / Heating
4: 79 percent / m-CPBA / CH2Cl2; H2O / 3 h / 20 °C / pH 7
5: 84 percent / tributylphosphine / Pd(OAc)2 / 2-methyl-propan-2-ol / 4 h / Heating
6: CH2Cl2 / Photolysis
7: 81 percent / proton sponge / CH2Cl2 / 48 h / 20 °C
8: 80 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / balloon pressure
With
pyridine; Proton Sponge; tributylphosphine; di-isopropyl azodicarboxylate; hydrogen; tert-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium diacetate; palladium on activated charcoal; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/ol047507p
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / pyridine / CH2Cl2 / 1.5 h / 20 °C
2: 80 percent / tBuNH2 / PdCl2(dppf)*CH2Cl2 / propan-2-ol; H2O / Heating
3: 79 percent / m-CPBA / CH2Cl2; H2O / 3 h / 20 °C / pH 7
4: 84 percent / tributylphosphine / Pd(OAc)2 / 2-methyl-propan-2-ol / 4 h / Heating
5: CH2Cl2 / Photolysis
6: 81 percent / proton sponge / CH2Cl2 / 48 h / 20 °C
7: 80 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / balloon pressure
With
pyridine; Proton Sponge; tributylphosphine; hydrogen; tert-butylamine; 3-chloro-benzenecarboperoxoic acid;
palladium diacetate; palladium on activated charcoal; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
dichloromethane; water; ethyl acetate; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/ol047507p
