Technology Process of 2,4,6,8-Nonatetraenoic acid,9-(2-ethyl-6,6-dimethyl-1-cyclohexen- 1-yl)-3,7-dimethyl-,ethyl ester,(2E,4E,6E,8E)-
There total 6 articles about 2,4,6,8-Nonatetraenoic acid,9-(2-ethyl-6,6-dimethyl-1-cyclohexen- 1-yl)-3,7-dimethyl-,ethyl ester,(2E,4E,6E,8E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran; tert-butyl alcohol;
at 55 ℃;
for 16h;
DOI:10.1021/jm00183a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LDA / 1.) THF, Et2O, hexane, 2.) THF, Et2O, hexane, -15 deg C, 3.5 h
2: oxalic acid / H2O; tetrahydrofuran; diethyl ether; hexane / 15 h / Ambient temperature
4: PBr3, pyridine / hexane; diethyl ether / 1.75 h / -5 - 0 °C
5: CH2Cl2 / 68 h / Ambient temperature
6: 48 percent / KO-t-BU / 2-methyl-propan-2-ol; tetrahydrofuran / 16 h / 55 °C
With
pyridine; potassium tert-butylate; oxalic acid; phosphorus tribromide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm00183a010
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) LDA / 1.) THF, 0 deg C, 40 min, 2.) THF, -78 deg C, 1 h
2: 1.) MeI, 2.) 0.1 N aq. NaHCO3 / 1.) aq. EtOH, reflux, 4.25 h, 2.) benzene, RT, overnight
3: 1.) LDA / 1.) THF, Et2O, hexane, 2.) THF, Et2O, hexane, -15 deg C, 3.5 h
4: oxalic acid / H2O; tetrahydrofuran; diethyl ether; hexane / 15 h / Ambient temperature
6: PBr3, pyridine / hexane; diethyl ether / 1.75 h / -5 - 0 °C
7: CH2Cl2 / 68 h / Ambient temperature
8: 48 percent / KO-t-BU / 2-methyl-propan-2-ol; tetrahydrofuran / 16 h / 55 °C
With
pyridine; potassium tert-butylate; oxalic acid; phosphorus tribromide; sodium hydrogencarbonate; lithium diisopropyl amide; methyl iodide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm00183a010
