N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide

Base Information

Chemical Name:N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide
CAS No.:117820-36-7
Molecular Formula:C15H15 N O5
Molecular Weight:289.2833
Hs Code.:
Nikkaji Number:J979.795E
Metabolomics Workbench ID:98503
Mol file:117820-36-7.mol

Synonyms:2880 II;2880-II;N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide;Streptomyces metabolite 2880 II

Suppliers and Price of N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide

Chemical Property:

Vapor Pressure:8.36E-14mmHg at 25°C
Boiling Point:569.4°Cat760mmHg
Flash Point:298.2°C
Density:1.39g/cm³
XLogP3:1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:289.09502258
Heavy Atom Count:21
Complexity:483

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)C=CC(=O)NC2=C(CCC2=O)O)O
Isomeric SMILES:COC1=C(C=CC(=C1)/C=C/C(=O)NC2=C(CCC2=O)O)O

Technology Process of N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide

There total 4 articles about N-(3-Hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl)propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: (E)-3-Bromo-N-(2-hydroxy-5-oxo-cyclopent-1-enyl)-acrylamide

: 2-Methoxy-4-tributylstannanyl-phenol

: 117820-36-7
(E)-N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl) propenamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1016/S0040-4020(98)00536-5

Reference yield: 29.0%

: 134896-05-2
(E)-N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-<4-(acetyloxy)-3-methoxyphenyl> propenamide

: 117820-36-7
(E)-N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl) propenamide

Guidance literature:: With ammonia; In methanol; at 23 ℃; for 0.5h;
DOI:10.1080/00397919108016756

Reference yield:

: 2596-47-6,147677-05-2,34749-55-8
(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid

: 117820-36-7
(E)-N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-(4-hydroxy-3-methoxyphenyl) propenamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / 0 - 23 °C

2: 50 percent / DMAP, pyridine / 24 h / 23 °C

3: 29 percent / NH₃ / methanol / 0.5 h / 23 °C

With pyridine; dmap; oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1080/00397919108016756