Technology Process of 1H-Indole-1-acetic acid, 3-(4-chlorophenoxy)-4-iodo-2-methyl-, ethyl
ester
There total 6 articles about 1H-Indole-1-acetic acid, 3-(4-chlorophenoxy)-4-iodo-2-methyl-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid ethyl ester;
With
sulfuric acid; sodium nitrite;
In
water;
at 0 ℃;
for 0.25h;
With
potassium iodide;
In
water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen; triethylamine / 5%-palladium/activated carbon / ethyl acetate / 6 h / 20 °C / 760.05 Torr
2.1: sulfuric acid; sodium nitrite / water / 0.25 h / 0 °C
2.2: 1 h / 20 °C
With
sulfuric acid; hydrogen; triethylamine; sodium nitrite;
5%-palladium/activated carbon;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h
1.2: 5 h
2.1: sodium hydrogencarbonate; phosphorus trichloride / tetrahydrofuran / 20 h / 70 °C
3.1: sodium t-butanolate / tetrahydrofuran / 0.5 h
4.1: hydrogen; triethylamine / 5%-palladium/activated carbon / ethyl acetate / 6 h / 20 °C / 760.05 Torr
5.1: sulfuric acid; sodium nitrite / water / 0.25 h / 0 °C
5.2: 1 h / 20 °C
With
sulfuric acid; hydrogen; sodium hydrogencarbonate; triethylamine; sodium t-butanolate; sodium nitrite; phosphorus trichloride;
5%-palladium/activated carbon;
In
tetrahydrofuran; water; ethyl acetate;
