1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))-

Base Information

Chemical Name:1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))-
CAS No.:74674-96-7
Molecular Formula:C₁₉H₃₅NO
Molecular Weight:293.493
Hs Code.:
Mol file:74674-96-7.mol

Synonyms:1-Azaspiro[5.5]undecan-8-ol,7-butyl-2-(4-pentenyl)-, [6R-[6a(R*),7b,8a]]-; C5-Decahydro-HTX; C5-Decahydrohistrionicotoxin;Histrionicotoxin, C5-decahydro-

Suppliers and Price of 1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))-

Chemical Property:

Vapor Pressure:2.05E-08mmHg at 25°C
Boiling Point:409.5°C at 760 mmHg
Flash Point:55.4°C
Density:0.95g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))-

There total 12 articles about 1-Azaspiro(5.5)undecan-8-ol, 7-butyl-2-(4-pentenyl)-, (6R-(6alpha(R*), 7beta,8alpha))- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 81497-18-9
rel-(6S,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undec-1-ene

: 81521-84-8,74674-96-7
rel-(2R,6R,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undecane

: 81521-85-9,74674-96-7
rel-(2S,6R,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undecane

Guidance literature:: With aluminium hydride; In toluene; Yields of byproduct given; 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h;
DOI:10.1021/ja00377a026

Reference yield: 71.0%

: 81497-18-9
rel-(6S,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undec-1-ene

: 81521-84-8,74674-96-7
rel-(2R,6R,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undecane

: 81521-85-9,74674-96-7
rel-(2S,6R,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undecane

Guidance literature:: With aluminium hydride; In toluene; Yields of byproduct given; 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h;
DOI:10.1021/ja00377a026

Reference yield:

: 81521-86-0
6-Hydroxy-6-((E)-non-4-enyl)-piperidin-2-one

: 81521-84-8,74674-96-7
rel-(2R,6R,7S,8S)-7-butyl-8-hydroxy-2-(4-pentenyl)-1-azaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 6 steps

1: 33 percent / 32 h / 25 °C

2: 0.95 g / phosphorus pentasulfide / benzene / 4 h / Heating

3: 91 percent / sodium hydroxide / methanol / 3 h / 25 °C

4: 100 percent / CH₂Cl₂ / 18 h / Ambient temperature

5: 1.) magnesium, 2.) magnesium chloride / 1.) ether, 2.) dichloromethane, reflux, 24 h

6: 71 percent / aluminum hydride / toluene / 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h

With aluminium hydride; diphosphorus pentasulfide; sodium hydroxide; magnesium; magnesium chloride; In methanol; dichloromethane; toluene; benzene;
DOI:10.1021/ja00377a026