triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

Base Information

Chemical Name:triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester
CAS No.:132062-50-1
Molecular Formula:C12H16N3O13P3
Molecular Weight:503.189
Hs Code.:

Synonyms:

Suppliers and Price of triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

Chemical Property:

Vapor Pressure:3.61E-28mmHg at 25°C
Boiling Point:816.2°Cat760mmHg
Flash Point:447.4°C
Density:2.19g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

There total 5 articles about triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(4-nitro-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131487-19-9
2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-α/β-D-glycero-pentofuranosyl chloride

: 132062-50-1
C₁₂H₁₆N₃O₁₃P₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1) tris<2-(2-methoxyethoxy)ethyl>amine, K₂CO₃ / 1) acetonitrile, room temp., 50 min; 2) acetonitrile, room temp., 60 min

2: 79 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

3: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With tributyl-amine; Tris(3,6-dioxaheptyl)amine; tetrabutyl ammonium fluoride; potassium carbonate; tri(n-butyl)ammonium pyrophosphate; trichlorophosphate; In tetrahydrofuran;
DOI:10.1002/hlca.19910740514

Reference yield:

: 221459-89-8
(2RS,5S)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>tetrahydrofuran-2-ol

: 132062-50-1
C₁₂H₁₆N₃O₁₃P₃

Guidance literature:: Multi-step reaction with 4 steps

1: tris(dimethylamino)phosphane, CCl₄ / tetrahydrofuran; CCl₄ / 2 h / -78 °C

2: 1) tris<2-(2-methoxyethoxy)ethyl>amine, K₂CO₃ / 1) acetonitrile, room temp., 50 min; 2) acetonitrile, room temp., 60 min

3: 79 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

4: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With tetrachloromethane; tributyl-amine; Tris(3,6-dioxaheptyl)amine; tetrabutyl ammonium fluoride; potassium carbonate; tri(n-butyl)ammonium pyrophosphate; Hexamethylphosphorous triamide; trichlorophosphate; In tetrahydrofuran; tetrachloromethane;
DOI:10.1002/hlca.19910740514

Reference yield:

: 83683-82-3
4-nitro-1H-pyrrolo<2,3-b>pyridine

: 132062-50-1
C₁₂H₁₆N₃O₁₃P₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1) tris<2-(2-methoxyethoxy)ethyl>amine, K₂CO₃ / 1) acetonitrile, room temp., 50 min; 2) acetonitrile, room temp., 60 min

2: 79 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

3: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With tributyl-amine; Tris(3,6-dioxaheptyl)amine; tetrabutyl ammonium fluoride; potassium carbonate; tri(n-butyl)ammonium pyrophosphate; trichlorophosphate; In tetrahydrofuran;
DOI:10.1002/hlca.19910740514