Benidipine

Base Information

Chemical Name:Benidipine
CAS No.:105979-17-7
Molecular Formula:C28H31N3O6
Molecular Weight:505.571
Hs Code.:
European Community (EC) Number:857-680-4
UNII:4G9T91JS7E
DSSTox Substance ID:DTXSID0022648
Wikipedia:Benidipine
NCI Thesaurus Code:C81680
Metabolomics Workbench ID:152263
ChEMBL ID:CHEMBL2105555,CHEMBL3303980
Mol file:105979-17-7.mol

Synonyms:benidipine

Suppliers and Price of Benidipine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
racBenidipine
0.5mg
$ 45.00

Medical Isotopes, Inc.
Benidipine
25 mg
$ 1500.00

AvaChem
Benidipine
1g
$ 289.00

AvaChem
Benidipine
100mg
$ 89.00

American Custom Chemicals Corporation
CONIEL 95.00%
1G
$ 1501.50

American Custom Chemicals Corporation
CONIEL 95.00%
100MG
$ 693.00

Total 89 raw suppliers

Chemical Property of Benidipine

Chemical Property:

Vapor Pressure:1.5E-15mmHg at 25°C
Refractive Index:1.621
Boiling Point:625.2 °C at 760 mmHg
PKA:pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Flash Point:331.9 °C
PSA：113.69000
Density:1.29 g/cm³
LogP:5.00030
Water Solubility.:316μg/L at 25℃
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:505.22128572
Heavy Atom Count:37
Complexity:933

Purity/Quality:

97% ^*data from raw suppliers

racBenidipine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OC2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC
Isomeric SMILES:CC1=C([C@H](C(=C(N1)C)C(=O)O[C@@H]2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC
Recent ClinicalTrials:Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension
Recent NIPH Clinical Trials:ACRoss-AMI
Uses Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

Technology Process of Benidipine

There total 7 articles about Benidipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6859-99-0
3-hydroxypiperazine

: 105979-17-7,119065-61-1,119065-60-0,91599-75-6
benidipine

Guidance literature:: Multi-step reaction with 3 steps

2: triethylamine / toluene / 5 h / Heating

3: dimethylformamide; CH₂Cl₂ / 2 h

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 62414-68-0
(3R)-piperidin-3-ol

: 105979-17-7,119065-61-1,119065-60-0,91599-75-6
benidipine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / toluene / 5 h / Heating

2: dimethylformamide; CH₂Cl₂ / 2 h

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 76093-34-0
(+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid

: 105979-17-7,119065-61-1,119065-60-0,91599-75-6
benidipine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

2: dimethylformamide; CH₂Cl₂ / 2 h

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;