2-Thiazoleheptanoic acid, 4-(4-methoxyphenyl)-

Base Information

• Chemical Name: 2-Thiazoleheptanoic acid, 4-(4-methoxyphenyl)-
• CAS No.: 847265-46-7
• Molecular Formula: C17H21NO3S
• Molecular Weight: 319.425
• Mol file: 847265-46-7.mol

Synonyms:

Chemical Property of 2-Thiazoleheptanoic acid, 4-(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiazoleheptanoic acid, 4-(4-methoxyphenyl)-

There total 6 articles about 2-Thiazoleheptanoic acid, 4-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-[4-(4-methoxyphenyl)thiazol-2-yl]heptanal (847266-93-7) → 7-[4-(4-methoxyphenyl)thiazol-2-yl]heptanoic acid (847265-46-7)

Guidance literature:

With sodium hypochlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.666667h;

Reference yield:

7-[4-(4-methoxy-phenyl)-thiazol-2-yl]-heptanoic acid methyl ester → 7-[4-(4-methoxyphenyl)thiazol-2-yl]heptanoic acid (847265-46-7)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2003.07.012

Reference yield:

suberic acid monomethyl ester (3946-32-5) → 7-[4-(4-methoxyphenyl)thiazol-2-yl]heptanoic acid (847265-46-7)

Guidance literature:

Multi-step reaction with 5 steps

1: (COCl)2; DMF / CH₂Cl₂

2: aq. NH₃ / tetrahydrofuran

3: Lawesson's reagent / benzene / 1.5 h / 70 °C

4: methanol / 20 °C

5: aq. NaOH / methanol

With Lawessons reagent; ammonium hydroxide; sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; benzene;

DOI:10.1016/j.bmcl.2003.07.012

upstream raw materials:

suberic acid monomethyl ester

methyl 8-chloro-8-oxooctanoate

suberamic acid methyl ester

7-[4-(4-methoxyphenyl)thiazol-2-yl]heptanal