1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)-

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)-
CAS No.:847358-35-4
Molecular Formula:C31H43NO3Si
Molecular Weight:505.773
Hs Code.:

1(2H)-Pyridinecarboxylic acid,
3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2-
propenyl)-, methyl ester, (2S,3R)-

Synonyms:

Suppliers and Price of 1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)-

There total 11 articles about 1(2H)-Pyridinecarboxylic acid, 3-butyl-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,4-dihydro-6-(2- propenyl)-, methyl ester, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24850-33-7
allyltributylstanane

: 847358-34-3
(2S,3R)-(-)-3-butyl-2-(tert-butyldiphenylsilanyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydropyridine-1(2H)-carboxylic acid methyl ester

: 847358-35-4
(2S,3R)-(-)-6-allyl-3-butyl-2-(tert-butyldiphenylsilanyloxymethyl)-3,4-dihydropyridine-1(2H)-carboxylic acid methyl ester

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; for 4h;
DOI:10.1016/j.tet.2004.11.060

Reference yield:

: 847358-25-2
(R)-(+)-propionic acid 2-(hydroxymethyl)hexyl ester

: 847358-35-4
(2S,3R)-(-)-6-allyl-3-butyl-2-(tert-butyldiphenylsilanyloxymethyl)-3,4-dihydropyridine-1(2H)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 15 steps

1.1: PPTS / CH₂Cl₂ / 6 h / 20 °C

2.1: MeOH; K₂CO₃ / 19 h / 20 °C

3.1: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1.5 h / -78 - 0 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

4.2: tetrahydrofuran; hexane / 22 h / 20 °C

5.1: (DHQD)2PYR; K₃Fe(CN)6; K₂CO₃ / K₂OsO₄ / 2-methyl-propan-2-ol; H₂O / 17 h / 0 °C

6.1: Et₃N; DMAP / CH₂Cl₂ / 45 h / 20 °C

7.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

8.1: NaN₃ / dimethylformamide / 15 h / 80 °C

9.1: PPTS; EtOH / 2 h / 60 °C

10.1: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1.5 h / -78 - 0 °C

11.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

11.2: tetrahydrofuran / 2 h / 20 °C

12.1: hydrogen / Pd/C / ethyl acetate / 48 h / 3040 Torr

13.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

14.1: hexamethyldisilazane; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

14.2: tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C

15.1: LiCl / Pd(PPh₃)4 / tetrahydrofuran / 4 h / 70 °C

With methanol; dmap; n-butyllithium; sodium azide; oxalyl dichloride; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; ethanol; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; potassium hexacyanoferrate(III); potassium osmate(VI); palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Swern oxidation / 4.2: Wittig reaction / 5.1: Sharpless asymmetric dihydroxylation / 10.1: Swern oxidation / 11.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2004.11.060

Reference yield:

: (R)-2-(Tetrahydro-pyran-2-yloxymethyl)-hexanal

: 847358-35-4
(2S,3R)-(-)-6-allyl-3-butyl-2-(tert-butyldiphenylsilanyloxymethyl)-3,4-dihydropyridine-1(2H)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: tetrahydrofuran; hexane / 22 h / 20 °C

2.1: (DHQD)2PYR; K₃Fe(CN)6; K₂CO₃ / K₂OsO₄ / 2-methyl-propan-2-ol; H₂O / 17 h / 0 °C

3.1: Et₃N; DMAP / CH₂Cl₂ / 45 h / 20 °C

4.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.1: NaN₃ / dimethylformamide / 15 h / 80 °C

6.1: PPTS; EtOH / 2 h / 60 °C

7.1: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1.5 h / -78 - 0 °C

8.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

8.2: tetrahydrofuran / 2 h / 20 °C

9.1: hydrogen / Pd/C / ethyl acetate / 48 h / 3040 Torr

10.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

11.1: hexamethyldisilazane; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

11.2: tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C

12.1: LiCl / Pd(PPh₃)4 / tetrahydrofuran / 4 h / 70 °C

With dmap; n-butyllithium; sodium azide; oxalyl dichloride; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; ethanol; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; potassium hexacyanoferrate(III); potassium osmate(VI); palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 1.2: Wittig reaction / 2.1: Sharpless asymmetric dihydroxylation / 7.1: Swern oxidation / 8.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2004.11.060