Technology Process of Imidazo[1,2-a]pyridine-2-acetic acid,
5,6,7,8-tetrahydro-6,7,8-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-,
methyl ester, (5R,6R,7S,8S)-
There total 2 articles about Imidazo[1,2-a]pyridine-2-acetic acid,
5,6,7,8-tetrahydro-6,7,8-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-,
methyl ester, (5R,6R,7S,8S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: CH2Cl2; acetic acid / 0.08 h
1.2: 3 percent / NaBH(OAc)3 / CH2Cl2; acetic acid / 16 h / 22 °C
2.1: 64 percent / hydrogen / Pd/C / methanol / 5 h / 22 °C / atmospheric pressure
3.1: HgCl2 / tetrahydrofuran / 18 h / 22 °C
3.2: 44 percent / TsOH*H2O / toluene / 40 h / 60 °C
With
hydrogen; mercury dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1002/hlca.200490273
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 64 percent / hydrogen / Pd/C / methanol / 5 h / 22 °C / atmospheric pressure
2.1: HgCl2 / tetrahydrofuran / 18 h / 22 °C
2.2: 44 percent / TsOH*H2O / toluene / 40 h / 60 °C
With
hydrogen; mercury dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1002/hlca.200490273