Methanesulfonamide, N-[3-[4-(2-cyclohexylideneethyl)-3,4-dihydro-1-hydroxy-4-methyl-3-oxo- 2-naphthalenyl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]-

Base Information

• Chemical Name: Methanesulfonamide, N-[3-[4-(2-cyclohexylideneethyl)-3,4-dihydro-1-hydroxy-4-methyl-3-oxo- 2-naphthalenyl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]-
• CAS No.: 847442-09-5
• Molecular Formula: C27H29N3O6S2
• Molecular Weight: 555.676
• Mol file: 847442-09-5.mol

Synonyms:

Chemical Property of Methanesulfonamide, N-[3-[4-(2-cyclohexylideneethyl)-3,4-dihydro-1-hydroxy-4-methyl-3-oxo- 2-naphthalenyl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonamide, N-[3-[4-(2-cyclohexylideneethyl)-3,4-dihydro-1-hydroxy-4-methyl-3-oxo- 2-naphthalenyl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]-

There total 6 articles about Methanesulfonamide, N-[3-[4-(2-cyclohexylideneethyl)-3,4-dihydro-1-hydroxy-4-methyl-3-oxo- 2-naphthalenyl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

N-[3-(4-allyl-1-hydroxy-4-methyl-3-oxo-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide (847441-85-4) + methylidenecyclobutane (1120-56-5) → N-{3-[4-(2-cyclohexylideneethyl)-1-hydroxy-4-methyl-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (847442-09-5)

Guidance literature:

1,3-(bis-(mesityl)-2-imidazolidinylidene)dichloro(phenylmethylene)-(o-isopropoxyphenylmethylene)ruthenium; In 1,2-dichloro-ethane; at 70 ℃; for 18.033h;

Reference yield:

2-chloro-5-nitrobenzenesulfonamide (96-72-0) → N-{3-[4-(2-cyclohexylideneethyl)-1-hydroxy-4-methyl-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (847442-09-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / (NH₄)2CO₃; CuSO₄; aq. NH₃ / 4 h / 120 °C

2: 70 percent / Na₂S₂O₄; aq. NaOH

3: 68 percent / pyridine / CH₂Cl₂ / 18 h

4: 46 percent / dioxane / 18 h / 85 °C

5: Hoveyda-Grubbs 2nd generation catalyst / CH₂Cl₂ / 70 °C

With pyridine; ammonium hydroxide; sodium hydroxide; sodium dithionite; ammonium carbonate; copper(II) sulfate; Hoveyda-Grubbs catalyst second generation; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.072

Reference yield:

2,5-diaminobenzenesulfonamide (20896-44-0) → N-{3-[4-(2-cyclohexylideneethyl)-1-hydroxy-4-methyl-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (847442-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / pyridine / CH₂Cl₂ / 18 h

2: 46 percent / dioxane / 18 h / 85 °C

3: Hoveyda-Grubbs 2nd generation catalyst / CH₂Cl₂ / 70 °C

With pyridine; Hoveyda-Grubbs catalyst second generation; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.072

upstream raw materials:

N-[3-(4-allyl-1-hydroxy-4-methyl-3-oxo-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide

methylenecyclohexane

2-amino-5-(methanesulfonylamino)benzenesulfonamide

2-chloro-5-nitrobenzenesulfonamide