phenyl(2-phenylcyclopropyl)methanone

Base Information

• Chemical Name: phenyl(2-phenylcyclopropyl)methanone
• CAS No.: 1145-92-2
• Molecular Formula: C16H14 O
• Molecular Weight: 222.287
• Mol file: 1145-92-2.mol

Synonyms:Ketone,phenyl 2-phenylcyclopropyl, trans- (8CI); Methanone,phenyl(2-phenylcyclopropyl)-, trans-; NSC 168921;trans-1-Benzoyl-2-phenylcyclopropane

Chemical Property of phenyl(2-phenylcyclopropyl)methanone

Chemical Property:

• Vapor Pressure: 2.73E-05mmHg at 25°C
• Boiling Point: 357.4°Cat760mmHg
• Flash Point: 155.1°C
• Density: 1.143g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl(2-phenylcyclopropyl)methanone

There total 47 articles about phenyl(2-phenylcyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

trimethylsulfoxonium iodide (1774-47-6) + 1,3-diphenyl-propen-3-one (614-47-1) → (1SR,2SR)-phenyl(2-phenylcyclopropyl)ketone (1145-92-2)

Guidance literature:

With potassium hydroxide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(03)00732-9

Reference yield: 93.0%

trimethylsulphoxonium iodide (1030268-24-6) + 1,3-diphenyl-propen-3-one (614-47-1) → (1SR,2SR)-phenyl(2-phenylcyclopropyl)ketone (1145-92-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; for 0.5h;

DOI:10.1080/00397910500521837

Reference yield: 91.0%

trimethylsulfoxonium iodide (1774-47-6) + benzalacetophenone (94-41-7) → (1SR,2SR)-phenyl(2-phenylcyclopropyl)ketone (1145-92-2)

Guidance literature:

With [PAIM][NTf₂]; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153339

upstream raw materials:

(+/-)-trans-2-phenylcyclopropanecarbonitrile

benzoic acid methyl ester

1,1-dibromo-2-phenylcyclopropane

4-(4-chlorophenyl)-4-hydroxypiperidine

Downstream raw materials:

N-(4-Oxo-1,4-diphenyl-butyl)-acetamide

Refernces

• 1、 Yanovskaya,L.A. et al.. "-". . p. 1565 - 1573. Retrieved 1972.
• 2、 Malunavar, Shruti S.,Sutar, Suraj M.,Prabhala, Pavankumar,Savanur, Hemantkumar M.,Kalkhambkar, Rajesh G.,Aridoss, Gopalakrishnan,Laali, Kenneth K.. "Facile synthesis of libraries of functionalized cyclopropanes and oxiranes using ionic liquids – A new approach to the classical Corey-Chaykovsky reaction". supporting information. . Retrieved 2021/09/13.
• 3、 Luo, Wenping,Fang, Yewen,Zhang, Li,Xu, Tianhang,Liu, Yongjun,Li, Yan,Jin, Xiaoping,Bao, Jiakan,Wu, Xiaodong,Zhang, Zongyong. "Bromomethyl Silicate: A Robust Methylene Transfer Reagent for Radical-Polar Crossover Cyclopropanation of Alkenes". supporting information. p. 1778 - 1781. Retrieved 2020/03/11.