3,4-Difluoro-2-methylbenzyl alcohol

Base Information

Chemical Name:3,4-Difluoro-2-methylbenzyl alcohol
CAS No.:847502-86-7
Molecular Formula:C₈H₈F₂O
Molecular Weight:158.148
Hs Code.:
DSSTox Substance ID:DTXSID501289381

Synonyms:3,4-DIFLUORO-2-METHYLBENZYL ALCOHOL;(3,4-difluoro-2-methylphenyl)methanol;847502-86-7;3,4-difluoro-2-methylBenzenemethanol;SCHEMBL4621597;NTTCNPWHTYWDLK-UHFFFAOYSA-N;DTXSID501289381;MFCD07777158;AKOS027425850;SB84015;CS-0194067;E90080

Suppliers and Price of 3,4-Difluoro-2-methylbenzyl alcohol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,4-Difluoro-2-methylbenzylalcohol
1g
$ 60.00

TRC
3,4-Difluoro-2-methylbenzylalcohol
500mg
$ 45.00

AOBChem
3,4-Difluoro-2-methylbenzyl alcohol
25g
$ 3850.00

AOBChem
3,4-Difluoro-2-methylbenzylalcohol 97%
10g
$ 1960.00

AOBChem
3,4-Difluoro-2-methylbenzylalcohol 97%
5g
$ 1152.00

AOBChem
3,4-Difluoro-2-methylbenzylalcohol 97%
1g
$ 322.00

AOBChem
3,4-Difluoro-2-methylbenzyl alcohol
500mg
$ 230.00

Total 6 raw suppliers

Chemical Property of 3,4-Difluoro-2-methylbenzyl alcohol

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:158.05432120
Heavy Atom Count:11
Complexity:129

Purity/Quality:

97% ^*data from raw suppliers

3,4-Difluoro-2-methylbenzylalcohol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1F)F)CO

Technology Process of 3,4-Difluoro-2-methylbenzyl alcohol

There total 2 articles about 3,4-Difluoro-2-methylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 157652-31-8
3,4-difluoro-2-methyl benzoic acid

: 847502-86-7
(3,4-difluoro-2-methylphenyl)methanol

Guidance literature:: 3,4-difluoro-2-methyl benzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Reflux;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 21h;

Reference yield:

: 847502-82-3
3,4-difluoro-2-methylbenzoyl chloride

: 847502-86-7
(3,4-difluoro-2-methylphenyl)methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 847502-86-7
(3,4-difluoro-2-methylphenyl)methanol

: (1S,3S)-methyl 1-(3,4-difluoro-2-methylphenyl)-3-hydroxycyclopentanecarboxylate

: (1R,3S)-methyl 1-(3,4-difluoro-2-methylphenyl)-3-hydroxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 h / 4 - 20 °C

2.1: N,N-dimethyl-formamide; water / 3 h / 4 °C

3.1: acetic acid; sulfuric acid; water / 24 h / Reflux

4.1: sulfuric acid / 20 h / Reflux

5.1: 18-crown-6 ether / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 3 h / 20 °C

5.3: 2 h / 20 °C

With 18-crown-6 ether; carbon tetrabromide; sulfuric acid; water; acetic acid; triphenylphosphine; In dichloromethane; water; N,N-dimethyl-formamide;