Technology Process of 3-Azetidinecarboxylic acid,
1-[[6-(2,2-dimethyl-3-phenylpropoxy)-3,4-dihydro-1-methyl-2-naphthalen
yl]methyl]-, hydrochloride
There total 11 articles about 3-Azetidinecarboxylic acid,
1-[[6-(2,2-dimethyl-3-phenylpropoxy)-3,4-dihydro-1-methyl-2-naphthalen
yl]methyl]-, hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / water; ethyl acetate
2: trichlorophosphate
3: methyl-phenyl-thioether; trifluoroacetic acid
4: diamide; triphenylphosphine / tetrahydrofuran
5: sodium hydroxide; trimethyl orthoformate / tetrahydrofuran; methanol
6: hydrogenchloride / tetrahydrofuran; water
With
hydrogenchloride; methyl-phenyl-thioether; diamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; trimethyl orthoformate;
In
tetrahydrofuran; methanol; water; ethyl acetate;
2: Vilsmeier formylation / 4: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.11.048
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate
2: methyl-phenyl-thioether; trifluoroacetic acid
3: diamide; triphenylphosphine / tetrahydrofuran
4: sodium hydroxide; trimethyl orthoformate / tetrahydrofuran; methanol
5: hydrogenchloride / tetrahydrofuran; water
With
hydrogenchloride; methyl-phenyl-thioether; diamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; trimethyl orthoformate;
In
tetrahydrofuran; methanol; water;
1: Vilsmeier formylation / 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.11.048
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methyl-phenyl-thioether; trifluoroacetic acid
2: diamide; triphenylphosphine / tetrahydrofuran
3: sodium hydroxide; trimethyl orthoformate / tetrahydrofuran; methanol
4: hydrogenchloride / tetrahydrofuran; water
With
hydrogenchloride; methyl-phenyl-thioether; diamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; trimethyl orthoformate;
In
tetrahydrofuran; methanol; water;
2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.11.048
