Benzoic acid, 5-chloro-2-[(5-fluoro-2-pyridinyl)oxy]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 5-chloro-2-[(5-fluoro-2-pyridinyl)oxy]-, methyl ester
CAS No.:847729-96-8
Molecular Formula:C13H9ClFNO3
Molecular Weight:281.671
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 5-chloro-2-[(5-fluoro-2-pyridinyl)oxy]-, methyl ester

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Technology Process of Benzoic acid, 5-chloro-2-[(5-fluoro-2-pyridinyl)oxy]-, methyl ester

There total 4 articles about Benzoic acid, 5-chloro-2-[(5-fluoro-2-pyridinyl)oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 847729-95-7
methyl 2-[(5-aminopyridin-2-yl)oxy]-5-chlorobenzoate

: 847729-96-8
methyl 5-chloro-2-[(5-fluoropyridin-2-yl)oxy]benzoate

Guidance literature:: methyl 2-[(5-aminopyridin-2-yl)oxy]-5-chlorobenzoate; With tetrafluoroboric acid; sodium nitrite; In water; at 0 ℃; for 5h;

In chlorobenzene; at 140 ℃; for 0.666667h;

Reference yield:

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

: 847729-96-8
methyl 5-chloro-2-[(5-fluoropyridin-2-yl)oxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate

3.1: tetrafluoroboric acid; sodium nitrite / water / 5 h / 0 °C

3.2: 0.67 h / 140 °C

With tetrafluoroboric acid; hydrogen; potassium carbonate; sodium nitrite; 5%-palladium/activated carbon; In DMF (N,N-dimethyl-formamide); water; ethyl acetate;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 847729-96-8
methyl 5-chloro-2-[(5-fluoropyridin-2-yl)oxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate

3.1: tetrafluoroboric acid; sodium nitrite / water / 5 h / 0 °C

3.2: 0.67 h / 140 °C

With tetrafluoroboric acid; hydrogen; potassium carbonate; sodium nitrite; 5%-palladium/activated carbon; In DMF (N,N-dimethyl-formamide); water; ethyl acetate;