1,3-disulfanylpropan-2-one

Base Information

• Chemical Name: 1,3-disulfanylpropan-2-one
• CAS No.: 60973-55-9
• Molecular Formula: C₃H₆OS₂
• Molecular Weight: 122.212

Synonyms:1,3-Dimercapto-2-propanone;1,3-Dimercaptoacetone; NSC 207814

Chemical Property of 1,3-disulfanylpropan-2-one

Chemical Property:

• Vapor Pressure: 0.101mmHg at 25°C
• Boiling Point: 222.6°Cat760mmHg
• Flash Point: 88.4°C
• Density: 1.183g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-disulfanylpropan-2-one

There total 1 articles about 1,3-disulfanylpropan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-bis-mercaptomethyl-[1,4]dithiane-2,5-diol (859309-77-6) → 1,3-acetonedithiol (60973-55-9)

Guidance literature:

under 14 Torr;

Reference yield:

1,3-acetonedithiol (60973-55-9) → [1,2]dithiolan-4-one semicarbazone (1124-66-9)

Guidance literature:

With ethanol; iodine; Behandeln der Reaktionsloesung mit Semicarbazid-hydrochlorid und Natriumhydrogencarbonat;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1,3-acetonedithiol (60973-55-9) → 1,3-Bis(thiomethyl)acetone (39199-23-0)

Guidance literature:

With diethyl ether; acetone;

upstream raw materials:

2,5-bis-mercaptomethyl-[1,4]dithiane-2,5-diol

Downstream raw materials:

1,3-Bis(thiomethyl)acetone

[1,2]dithiolan-4-one semicarbazone

Refernces

Either diastereofacial differentiation in the reaction of chiral thiomethylketones with appropriate organometallics

10.1016/S0040-4039(00)97877-8

The research focuses on the development of a method for efficient diastereoselective synthesis of chiral tertiary alcohols by reacting chiral thiomethylketones with appropriate organometallic reagents. The study aimed to demonstrate that the introduction of a sulfur atom in place of oxygen at the α-position to the ketone was crucial for achieving high diastereoselectivity. The researchers found that the choice of organometallic reagent and reaction conditions significantly influenced the stereoselectivity of the reaction, allowing for the selective synthesis of either diastereomer of the tertiary alcohol. Key chemicals used in the process included a-thio carbonyl compounds, organolithium reagents like MeLi, organozinc reagents like MeZn, and chiral thiomethylketones derived from α-2-mercapto-2-phenylethanol and α-halo ketones. The study concluded that this method provided a useful approach for selectively synthesizing either enantiomer of tertiary alcohol starting from the same chiral carbonyl compound by choosing the appropriate organometallic reagent.

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