5-Hydroxypyrazinamide

Base Information

Chemical Name:5-Hydroxypyrazinamide
CAS No.:13924-96-4
Molecular Formula:C5H5N3O2
Molecular Weight:139.1121
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20160973
Nikkaji Number:J47.667F
Wikidata:Q63395802
Metabolomics Workbench ID:37959
Mol file:13924-96-4.mol

Synonyms:5-hydroxypyrazinamide

Suppliers and Price of 5-Hydroxypyrazinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Hydroxypyrazinecarboxamide
1g
$ 545.00

Medical Isotopes, Inc.
5-Hydroxypyrazinecarboxamide
500 mg
$ 650.00

Crysdot
5-Hydroxypyrazine-2-carboxamide 95+%
1g
$ 406.00

Crysdot
5-Hydroxypyrazine-2-carboxamide 95+%
5g
$ 1201.00

Chemenu
5-Hydroxypyrazine-2-carboxamide 95%
5g
$ 1131.00

Chemenu
5-Hydroxypyrazine-2-carboxamide 95%
1g
$ 383.00

Total 13 raw suppliers

Chemical Property of 5-Hydroxypyrazinamide

Chemical Property:

Vapor Pressure:5.65E-18mmHg at 25°C
Melting Point:292-295 °C
Refractive Index:1.696
Boiling Point:659 °C at 760 mmHg
PKA:10.69±0.40(Predicted)
Flash Point:352.4 °C
PSA：89.83000
Density:1.63 g/cm³
LogP:-0.24700
XLogP3:-1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:139.038176411
Heavy Atom Count:10
Complexity:241

Purity/Quality:

99% ^*data from raw suppliers

5-Hydroxypyrazinecarboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(N=CC(=O)N1)C(=O)N
Uses 5-Hydroxypyrazinecarboxamide is a metabolite of Pyrazinamide (P840600), an antibacterial (tuberculostatic).

Technology Process of 5-Hydroxypyrazinamide

There total 4 articles about 5-Hydroxypyrazinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5-oxo-4,5-dihydropyrazine-2-carbonitrile

: 13924-96-4
4,5-dihydro-5-oxo-2-pyrazinecarboxamide

Guidance literature:: With hydrogenchloride; water; at 40 ℃; for 24h;
DOI:10.1016/j.bmc.2019.01.007

Reference yield: 61.0%

: 77168-76-4
3-carbamoyl-1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid

: 13924-96-4
4,5-dihydro-5-oxo-2-pyrazinecarboxamide

Guidance literature:: With nitrobenzene; at 170 - 180 ℃; for 3h;
DOI:10.1248/cpb.28.3057

Reference yield:

: 57005-60-4
1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile

: 13924-96-4
4,5-dihydro-5-oxo-2-pyrazinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / 10percent Na₂CO₃ / 8 h / Heating

2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C

With sodium carbonate; nitrobenzene;
DOI:10.1248/cpb.28.3057