Chemical Property of Doxercalciferol
Chemical Property:
- Appearance/Colour:Crystalline solid
- Vapor Pressure:0mmHg at 25°C
- Melting Point:138-140 °C
- Refractive Index:1.541
- Boiling Point:538.7 °C at 760 mmHg
- PKA:14.43±0.40(Predicted)
- Flash Point:224 °C
- PSA：40.46000
- Density:1.01 g/cm3
- LogP:6.61180
- Storage Temp.:Desiccate at -20°C
- Solubility.:DMSO: >10mg/mL
- XLogP3:6.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:5
- Exact Mass:412.334130642
- Heavy Atom Count:30
- Complexity:712
- Purity/Quality:
-
99% *data from raw suppliers
Doxercalciferol *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+
- Statements:
28
- Safety Statements:
28-36/37-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
- Isomeric SMILES:C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
- Recent ClinicalTrials:Safety and Efficacy of Hectorol in Pediatric Patients With Chronic Kidney Disease Stage 3 and 4 With Secondary Hyperparathyroidism Not Yet on Dialysis
- Recent EU Clinical Trials:A Multicenter, Open-Label Study of Hectorol (doxercalciferol capsules) for the Treatment of Secondary Hyperparathyroidism
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Description
Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as
Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients
with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha-
D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in
5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the
liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile
similar to calcitriol. During placebo-controlled clinical trials, patients with
moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to
24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were
considerably reduced, so maintaining a good control of the parathyroid
hyperplasia. Moreover, only a moderate tendency to raise calcium and
phosphate was observed. Doxercalciferol is orally-active and less toxic than
other vitamin D analogs like alfacalcidol; it shows differentially controlled effects
and has an improved safety profile compared to calcitriol.
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Uses
Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma.
Antihyperparathyroid
