C-(2,2-Difluoro-cyclopropyl)-MethylaMine

Base Information

• Chemical Name: C-(2,2-Difluoro-cyclopropyl)-MethylaMine
• CAS No.: 847926-81-2
• Molecular Formula: C4H7F2N
• Molecular Weight: 107.10200
• Hs Code.: 2921300090
• Mol file: 847926-81-2.mol

Synonyms:

Chemical Property of C-(2,2-Difluoro-cyclopropyl)-MethylaMine

Chemical Property:

• PSA: 26.02000
• LogP: 1.30060

Purity/Quality:

98%min ^*data from raw suppliers

(2,2-Difluorocyclopropyl)methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2,2-Difluorocyclopropyl)methylamine is a difluorinated-derivative of Cyclopropylmethylamine (C988695) and is used as a reagent in the synthesis of pyrrolidine derivatives as alternative pathway modulators for the treatment of ophthalmic and other diseases. (2,2-Difluorocyclopropyl)methylamine is also used as the starting material in the synthesis of dihydrodiazepines as protein kinases inhibitors.

Technology Process of C-(2,2-Difluoro-cyclopropyl)-MethylaMine

There total 1 articles about C-(2,2-Difluoro-cyclopropyl)-MethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,2-difluorocyclopropylmethyl)isoindole-1,3-dione (1528563-83-8) → (2,2-difluorocyclopropyl)methylamine (847926-81-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 4h; Reflux; Inert atmosphere;

Reference yield:

4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one (1445993-88-3) + (2,2-difluorocyclopropyl)methylamine (847926-81-2) → C25H22F2N4O5S

Guidance literature:

In dimethyl sulfoxide; at 85 ℃; for 5h;

upstream raw materials:

2-(2,2-difluorocyclopropylmethyl)isoindole-1,3-dione

Refernces