5-hydroxyquinolin-2(1H)-one

Base Information

• Chemical Name: 5-hydroxyquinolin-2(1H)-one
• CAS No.: 31570-97-5
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933790090
• European Community (EC) Number: 851-185-7
• NSC Number: 134652
• DSSTox Substance ID: DTXSID40419213
• Nikkaji Number: J454.492G
• Wikidata: Q27121429
• Metabolomics Workbench ID: 57159
• Mol file: 31570-97-5.mol

Synonyms:5-hydroxyquinolin-2(1H)-one;31570-97-5;5-hydroxy-1H-quinolin-2-one;5-Hydroxy-2(1H)-quinolinone;quinoline-2,5-diol;5-hydroxy-2-quinolone;MFCD02181132;5-HYDROXY-1,2-DIHYDROQUINOLIN-2-ONE;5-hydroxyquinolone;2(1H)-Quinolinone, 5-hydroxy-;5-hydroxycarbostyril;NSC134652;2,5-Dihydroxyquinoline;5-oxidanyl-1H-quinolin-2-one;SCHEMBL3874061;CHEBI:48995;DTXSID40419213;XOXGLLQTNQBDKL-UHFFFAOYSA-N;BCP24371;AKOS005072168;CS-W004487;DA-0923;MB02360;NSC-134652;AM807161;SY110039;FT-0670096;EN300-170399;A820913;J-517622;Q27121429;Z1198306810

Chemical Property of 5-hydroxyquinolin-2(1H)-one

Chemical Property:

• Vapor Pressure: 4.73E-07mmHg at 25°C
• Melting Point: >300°C
• Refractive Index: 1.639
• Boiling Point: 402.4 °C at 760 mmHg
• PKA: 8.65±0.20(Predicted)
• Flash Point: 197.2 °C
• PSA: 53.09000
• Density: 1.337 g/cm³
• LogP: 1.23370
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.047678466
• Heavy Atom Count: 12
• Complexity: 225

Purity/Quality:

97% ^*data from raw suppliers

5-Hydroxyquinolin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=O)N2)C(=C1)O
• Uses: 5-Hydroxyquinolin-2(1H)-one (cas# 31570-97-5) is a compound useful in organic synthesis.

Technology Process of 5-hydroxyquinolin-2(1H)-one

There total 8 articles about 5-hydroxyquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone (15450-69-8) → 5-hydroxyquinolin-2(1H)-one (31570-97-5)

Guidance literature:

palladium on activated charcoal; In decalin; for 144h; Heating;

Reference yield: 90.0%

5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone (88877-00-3) → 5-hydroxyquinolin-2(1H)-one (31570-97-5)

Guidance literature:

With hydrogenchloride; Ambient temperature;

DOI:10.1055/s-1992-26090

Reference yield: 81.0%

3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone (5057-12-5) → 5-hydroxyquinolin-2(1H)-one (31570-97-5)

Guidance literature:

palladium on activated charcoal; In decalin; for 24h; Heating;

DOI:10.1021/jo00331a027

upstream raw materials:

quinolin-5-ol

3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone

5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone

5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone

Downstream raw materials:

N-methyl-5-methoxy-2(1H)-quinolinone

5-hydroxy-2-methoxyquinoline

5-methoxy-2(1H)-quinolinone

2-chloro-5-hydroxyquinoline