Chemical Property of CID 5472285
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:150-151℃
- Boiling Point:886.3°Cat760mmHg
- PKA:12.52±0.70(Predicted)
- Flash Point:252°C
- PSA：180.05000
- Density:1.14g/cm3
- LogP:5.88260
- Storage Temp.:−20°C
- Solubility.:Soluble in DMSO, ethanol or acetone
- XLogP3:7.1
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:3
- Exact Mass:790.52311317
- Heavy Atom Count:56
- Complexity:1390
- Purity/Quality:
-
99%, *data from raw suppliers
Oligomycin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,T
- Hazard Codes:Xn,T
- Statements:
22-68/20/21/22-20/21/22
- Safety Statements:
36/37-24/25
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
- Isomeric SMILES:CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)CC(C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
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Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.
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Uses
Oligomycin A is a macrolide with fungicidal activity isolated from Streptomyces species. Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumour and nematocidal activities. Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
