2,4(1H,3H)-Pyrimidinedione, 1-[[[(2E)-3-[4-(benzoyloxy)phenyl]-2-propenyl]oxy]methyl]-6-[(3,5-dimeth ylphenyl)methyl]-5-ethyl-

Base Information

• Chemical Name: 2,4(1H,3H)-Pyrimidinedione, 1-[[[(2E)-3-[4-(benzoyloxy)phenyl]-2-propenyl]oxy]methyl]-6-[(3,5-dimeth ylphenyl)methyl]-5-ethyl-
• CAS No.: 847995-38-4
• Molecular Formula: C32H32N2O5
• Molecular Weight: 524.616
• Mol file: 847995-38-4.mol

Synonyms:

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-[[[(2E)-3-[4-(benzoyloxy)phenyl]-2-propenyl]oxy]methyl]-6-[(3,5-dimeth ylphenyl)methyl]-5-ethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-[[[(2E)-3-[4-(benzoyloxy)phenyl]-2-propenyl]oxy]methyl]-6-[(3,5-dimeth ylphenyl)methyl]-5-ethyl-

There total 6 articles about 2,4(1H,3H)-Pyrimidinedione, 1-[[[(2E)-3-[4-(benzoyloxy)phenyl]-2-propenyl]oxy]methyl]-6-[(3,5-dimeth ylphenyl)methyl]-5-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(3,5-dimethylbenzyl)-5-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (171048-65-0) + benzoic acid (E)-4-[3-(methoxymethoxy)prop-1-enyl]phenyl ester (847995-36-2) → 6-(3,5-dimethylbenzyl)-5-ethyl-1-(methoxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione + benzoic acid 4-{3-[6-(3,5-dimethyl-benzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-propenyl}-phenyl ester (847995-38-4)

Guidance literature:

6-(3,5-dimethylbenzyl)-5-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 0.166667h;

benzoic acid (E)-4-[3-(methoxymethoxy)prop-1-enyl]phenyl ester; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃;

DOI:10.1021/jm040845b

Reference yield:

4-formylphenyl benzoate (5339-06-0) → benzoic acid 4-{3-[6-(3,5-dimethyl-benzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-propenyl}-phenyl ester (847995-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aq. K₂CO₃; tris[2-(2-methoxyethoxy)ethyl]amine / CH₂Cl₂ / 20 °C

1.2: 68 percent / aq. HCl / 20 °C

2.1: 78 percent / KH₂PO₄; NaBH₄ / methanol / 1 h / 0 °C

3.1: 97 percent / diisopropyl ethylamine / CH₂Cl₂ / 0 - 20 °C

4.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.17 h

4.2: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C

With sodium tetrahydroborate; potassium dihydrogenphosphate; N,O-bis-(trimethylsilyl)-acetamide; Tris(3,6-dioxaheptyl)amine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm040845b

Reference yield:

(E)-4-(3-hydroxyprop-1-enyl)phenol (20649-40-5) → benzoic acid 4-{3-[6-(3,5-dimethyl-benzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-propenyl}-phenyl ester (847995-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 58 percent / aq. NaOH / propan-2-ol / 0.5 h / 20 °C

2.1: 97 percent / diisopropyl ethylamine / CH₂Cl₂ / 0 - 20 °C

3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.17 h

3.2: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol; acetonitrile;

DOI:10.1021/jm040845b

upstream raw materials:

6-(3,5-dimethylbenzyl)-5-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

benzoic acid (E)-4-[3-(methoxymethoxy)prop-1-enyl]phenyl ester

4-formylphenyl benzoate

(E)-4-(3-hydroxyprop-1-enyl)phenol

Downstream raw materials:

6-(3,5-dimethyl-benzyl)-5-ethyl-1-[3-(4-hydroxy-phenyl)-allyloxymethyl]-1H-pyrimidine-2,4-dione