3-Butyn-2-ol, 4-[4-[[5-[[4-[[5-(dimethylamino)-1-naphthalenyl]ethynyl]phenyl]ethynyl]-1- naphthalenyl]ethynyl]phenyl]-2-methyl-

Base Information

• Chemical Name: 3-Butyn-2-ol, 4-[4-[[5-[[4-[[5-(dimethylamino)-1-naphthalenyl]ethynyl]phenyl]ethynyl]-1- naphthalenyl]ethynyl]phenyl]-2-methyl-
• CAS No.: 848073-07-4
• Molecular Formula: C45H33NO
• Molecular Weight: 603.763
• Mol file: 848073-07-4.mol

Synonyms:

Chemical Property of 3-Butyn-2-ol, 4-[4-[[5-[[4-[[5-(dimethylamino)-1-naphthalenyl]ethynyl]phenyl]ethynyl]-1- naphthalenyl]ethynyl]phenyl]-2-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Butyn-2-ol, 4-[4-[[5-[[4-[[5-(dimethylamino)-1-naphthalenyl]ethynyl]phenyl]ethynyl]-1- naphthalenyl]ethynyl]phenyl]-2-methyl-

There total 5 articles about 3-Butyn-2-ol, 4-[4-[[5-[[4-[[5-(dimethylamino)-1-naphthalenyl]ethynyl]phenyl]ethynyl]-1- naphthalenyl]ethynyl]phenyl]-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(3-hydroxy-3-methyl-1-butynyl)-1-iodobenzene (120517-37-5) + 1-(dimethylamino)-5-({4-[(5-ethynyl-1-naphthyl)ethynyl]-1-phenyl}ethynyl)naphthalene (848073-06-3) → 4-[4-({5-[(4-{[5-(dimethylamino)-1-naphthyl]ethynyl}-1-phenyl)ethynyl]-1-naphthyl}ethynyl)-1-phenyl]-2-methyl-3-butyn-2-ol (848073-07-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper (I) iodide; triethylamine; at 20 ℃; for 15h;

DOI:10.1002/ejoc.200400529

Reference yield:

4-(3-hydroxy-3-methyl-1-butynyl)-1-iodobenzene (120517-37-5) → 4-[4-({5-[(4-{[5-(dimethylamino)-1-naphthyl]ethynyl}-1-phenyl)ethynyl]-1-naphthyl}ethynyl)-1-phenyl]-2-methyl-3-butyn-2-ol (848073-07-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / triethylamine; [PdCl₂(PPh₃)2]; Cu₂I₂ / 15 h / 20 °C

2: 100 percent / sodium hydroxide / toluene / 4 h / Heating

3: 91 percent / triethylamine; [PdCl₂(PPh₃)2]; Cu₂I₂ / 10 h / 20 °C

4: 100 percent / sodium hydroxide / toluene / 4 h / Heating

5: 90 percent / triethylamine; [PdCl₂(PPh₃)2]; Cu₂I₂ / 15 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper (I) iodide; triethylamine; In toluene;

DOI:10.1002/ejoc.200400529

Reference yield:

4-(4-{[5-(dimethylamino)-1-naphthyl]ethynyl}-1-phenyl)-2-methyl-3-butyn-2-ol (557076-06-9) → 4-[4-({5-[(4-{[5-(dimethylamino)-1-naphthyl]ethynyl}-1-phenyl)ethynyl]-1-naphthyl}ethynyl)-1-phenyl]-2-methyl-3-butyn-2-ol (848073-07-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / sodium hydroxide / toluene / 4 h / Heating

2: 91 percent / triethylamine; [PdCl₂(PPh₃)2]; Cu₂I₂ / 10 h / 20 °C

3: 100 percent / sodium hydroxide / toluene / 4 h / Heating

4: 90 percent / triethylamine; [PdCl₂(PPh₃)2]; Cu₂I₂ / 15 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper (I) iodide; triethylamine; In toluene;

DOI:10.1002/ejoc.200400529

upstream raw materials:

4-(3-hydroxy-3-methyl-1-butynyl)-1-iodobenzene

1-(dimethylamino)-5-({4-[(5-ethynyl-1-naphthyl)ethynyl]-1-phenyl}ethynyl)naphthalene

4-(4-{[5-(dimethylamino)-1-naphthyl]ethynyl}-1-phenyl)-2-methyl-3-butyn-2-ol

5-[(4-ethynyl-1-phenyl)ethynyl]-N,N-dimethyl-naphthalen-1-amine