4-nitro-2-(trifluoromethyl)-1H-benzimidazole

Base Information

• Chemical Name: 4-nitro-2-(trifluoromethyl)-1H-benzimidazole
• CAS No.: 14689-51-1
• Molecular Formula: C8H4 F3 N3 O2
• Molecular Weight: 231.1315
• Mol file: 14689-51-1.mol

Synonyms:1H-Benzimidazole,4-nitro-2-(trifluoromethyl)- (9CI); Benzimidazole, 4-nitro-2-(trifluoromethyl)-(8CI); 4-Nitro-2-trifluoromethylbenzimidazole

Chemical Property of 4-nitro-2-(trifluoromethyl)-1H-benzimidazole

Chemical Property:

• Vapor Pressure: 3.82E-05mmHg at 25°C
• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.645g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-nitro-2-(trifluoromethyl)-1H-benzimidazole

There total 2 articles about 4-nitro-2-(trifluoromethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

trifluoroacetic acid (76-05-1) + 2,3-diamino-nitrobenzene (3694-52-8) → 4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole (14689-51-1)

Guidance literature:

DOI:10.1016/S0960-894X(98)00474-0

Reference yield:

2,3-diamino-nitrobenzene (3694-52-8) → 4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole (14689-51-1)

Guidance literature:

With trifluoroacetic anhydride; In toluene;

Reference yield: 58.0%

4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole (14689-51-1) → (4-((4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h; regioselective reaction;

DOI:10.1021/acs.jmedchem.5b01741

upstream raw materials:

trifluoroacetic acid

2,3-diamino-nitrobenzene