1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, hydrochloride

Base Information

Chemical Name:1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, hydrochloride
CAS No.:848086-69-1
Molecular Formula:C36H35ClF3NO3.ClH
Molecular Weight:658.588
Hs Code.:

1-Naphthalenecarboxylic acid,
5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino
]propoxy]-1,2,3,4-tetrahydro-, hydrochloride

Synonyms:

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Chemical Property of 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, hydrochloride

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Technology Process of 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, hydrochloride

There total 10 articles about 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 848086-69-1
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1.5 h / 20 °C

2: potassium carbonate / acetonitrile / 48 h / Heating / reflux

3: potassium carbonate; sodium iodide / acetonitrile / 16 h / Heating / reflux

4: lithium chloride / N,N-dimethyl-formamide / 5 h / Heating / reflux

5: hydrogenchloride / methanol

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium iodide; lithium chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 848171-53-9
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid

: 848086-69-1
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 405102-95-6
5-(benzyloxy)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

: 848086-69-1
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 2 h / Heating / reflux

2: hydrogen / palladium on activated charcoal / methanol / 16 h

3: potassium carbonate; sodium iodide / acetonitrile / 16 h / Heating / reflux

4: lithium chloride / N,N-dimethyl-formamide / 5 h / Heating / reflux

5: hydrogenchloride / methanol

With hydrogenchloride; sulfuric acid; hydrogen; potassium carbonate; sodium iodide; lithium chloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;