2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (2S)-

Base Information

• Chemical Name: 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (2S)-
• CAS No.: 848132-13-8
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241

Synonyms:

Chemical Property of 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (2S)-

Chemical Property:

Purity/Quality:

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Technology Process of 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (2S)-

There total 11 articles about 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-methyl 2-((tert-butoxycarbonyl)amino)-5-oxo-5-phenylpentanoate (1611470-49-5) → methyl (2S)-5-phenyl-3,4-dihydro-2H-2-pyrrolecarboxylate (848132-13-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

DOI:10.1002/ejoc.201601154

Reference yield: 74.0%

C25H23NO3 (1451253-15-8) → methyl (2S)-5-phenyl-3,4-dihydro-2H-2-pyrrolecarboxylate (848132-13-8)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/ol4019584

Reference yield: 50.0%

ethyl (S)-2-(4-methoxy-4-oxobutanamido)-5-oxo-5-phenylpentanoate → methyl (2S)-5-phenyl-3,4-dihydro-2H-2-pyrrolecarboxylate (848132-13-8)

Guidance literature:

With methanol; chloro-trimethyl-silane; at 0 ℃; Sealed tube; Reflux;

DOI:10.1002/anie.202006149

upstream raw materials:

(S)-2-Amino-5-phenyl-pent-4-ynoic acid methyl ester

methyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-phenyl-4-pentynoate

iodobenzene

methyl (2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate

Downstream raw materials:

β-1-Phenyl-1,2,3,4-tetradeoxy-1,4-imino-D-pentitol

methyl (2S,5R)-5-phenyltetrahydro-2H-2-pyrrolecarboxylate

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