2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

Chemical Name:2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
CAS No.:127945-77-1
Molecular Formula:C₁₀H₁₁N₅O₃
Molecular Weight:249.229
Hs Code.:
Mol file:127945-77-1.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,2-amino-7-(2,3-dihydroxypropyl)-4,7-dihydro-4-oxo- (9CI);1H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,2-amino-7-(2,3-dihydroxypropyl)-4,7-dihydro-4-oxo-, (?à)-

Suppliers and Price of 2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

Vapor Pressure:1.43E-08mmHg at 25°C
Boiling Point:441.4°Cat760mmHg
Flash Point:220.8°C
Density:1.75g/cm³

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 7 articles about 2-amino-7-(2,3-dihydroxypropyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 127945-61-3
2-amino-5-cyano-7-<(RS)-2,3-O-isopropylidene-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

: 127945-77-1
2-amino-5-cyano-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: With acetic acid; at 80 ℃; for 4h;
DOI:10.1021/jm00170a019

Reference yield: 30.0%

: 53106-70-0
2-chloro-2-formylacetonitrile

: 2-amino-6-[(2,3-dihydroxypropyl)amino]-4(3H)-pyrimidinone

: 127945-77-1
2-amino-5-cyano-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: With sodium acetate; In water; at 50 ℃; for 20h;
DOI:10.1016/j.tet.2003.11.030

Reference yield:

: 38187-09-6
2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

: 127945-77-1
2-amino-5-cyano-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h

2: 73 percent / Raney Ni / ethanol / 2 h / Heating

4: 74 percent / tosyl chloride, pyridine / Ambient temperature

5: 67 percent / 80percent aq. AcOH / 4 h / 80 °C

With pyridine; nickel; sodium hydride; acetic acid; p-toluenesulfonyl chloride; In ethanol;
DOI:10.1021/jm00170a019