1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester

Base Information

Chemical Name:1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester
CAS No.:848420-62-2
Molecular Formula:C33H34FN3O5
Molecular Weight:571.648
Hs Code.:

1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid,
2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl]
-4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester

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Chemical Property of 1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester

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Technology Process of 1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester

There total 5 articles about 1H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -4,5,6,7-tetrahydro-7-(1-methylethyl)-5-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 603999-18-4
ethyl (2Z)-3-amino-5-(4-fluorophenyl)-2-pentenoate

: 848420-57-5
4-Formyl-N-furan-2-ylmethylbenzamide

: 848420-61-1
(R)-5-isopropyl-pyrrolidine-2,4-dione trifluoroacetic acid

: 848420-62-2
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7-isopropyl-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Guidance literature:: With ammonia; In ethanol; water; at 115 ℃; for 17h;

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 848420-62-2
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7-isopropyl-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / dichloromethane / 20 °C

2: dmap / dichloromethane / 0 - 20 °C

3: Heating / reflux

4: ammonium acetate; acetic acid / toluene / Heating / reflux

5: ammonia / ethanol; water / 17 h / 115 °C

With dmap; oxalyl dichloride; ammonium acetate; ammonia; acetic acid; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 848420-62-2
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7-isopropyl-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16 h / 0 - 4 °C

2: ethyl acetate / 3 h / Heating / reflux

3: dichloromethane / 0.5 h

4: ammonia / ethanol; water / 17 h / 115 °C

With dmap; ammonia; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; water; ethyl acetate;