3-Quinolinecarboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester
CAS No.:848420-65-5
Molecular Formula:C34H33FN2O5
Molecular Weight:568.645
Hs Code.:

3-Quinolinecarboxylic acid,
2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl]
-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester

Synonyms:

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Chemical Property of 3-Quinolinecarboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester

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Technology Process of 3-Quinolinecarboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester

There total 4 articles about 3-Quinolinecarboxylic acid, 2-[2-(4-fluorophenyl)ethyl]-4-[4-[[(2-furanylmethyl)amino]carbonyl]phenyl] -5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

: 848420-65-5
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With ammonium cerium(IV) nitrate; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 848420-65-5
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / dichloromethane / 20 °C

2: dmap / dichloromethane / 0 - 20 °C

3: Heating / reflux

4: ethanol / 120 °C

5: ammonium cerium(IV) nitrate; trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With dmap; oxalyl dichloride; ammonium cerium(IV) nitrate; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

: 120465-56-7
4-(dimethoxymethyl)benzoic acid

: 848420-65-5
2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 16 h / 20 °C

2: ethanol / 120 °C

3: ammonium cerium(IV) nitrate; trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With dmap; ammonium cerium(IV) nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;