2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

Base Information

• Chemical Name: 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate
• CAS No.: 104777-03-9
• Molecular Formula: C₁₃H₁₅N₃O₅S
• Molecular Weight: 325.345
• Hs Code.: 2934999090
• Mol file: 104777-03-9.mol

Synonyms:Aceticacid, [[4-(3-methyl-5-isoxazolyl)-2-thiazolyl]amino]oxo-, 2-ethoxyethyl ester(9CI); Asobamast

Chemical Property of 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 131.79000
• Density: 1.363g/cm³
• LogP: 1.69770

Purity/Quality:

99% ^*data from raw suppliers

ASOBAMAST 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Antiallergic, Anti-asthmatic

Technology Process of 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

There total 3 articles about 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-ethoxyethyloxalyl chloride (74503-09-6) + 2-amino-4-(3-methyl-5-isoxazolyl)-thiazole (104776-85-4) → asobamast (104777-03-9)

Guidance literature:

With pyridine;

DOI:10.1021/jm00106a020

Reference yield:

5-acetyl-3-methylisoxazole (55086-61-8) → asobamast (104777-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / acetic acid, bromine / CHCl₃ / 48 - 50 °C

2: 57 percent / ethanol / 1.5 h / Heating

3: 91 percent / pyridine

With pyridine; bromine; acetic acid; In ethanol; chloroform;

DOI:10.1021/jm00106a020

Reference yield:

2-bromo-1-(3-methyl-1,2-oxazol-5-yl)ethanone (104777-32-4) → asobamast (104777-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / ethanol / 1.5 h / Heating

2: 91 percent / pyridine

With pyridine; In ethanol;

DOI:10.1021/jm00106a020

upstream raw materials:

2-ethoxyethyloxalyl chloride

2-amino-4-(3-methyl-5-isoxazolyl)-thiazole

5-acetyl-3-methylisoxazole

2-bromo-1-(3-methyl-1,2-oxazol-5-yl)ethanone