4-CHLORO-6-HYDROXYQUINAZOLINE

Base Information

• Chemical Name: 4-CHLORO-6-HYDROXYQUINAZOLINE
• CAS No.: 848438-50-6
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.593
• Hs Code.: 2933990090
• Mol file: 848438-50-6.mol

Synonyms:4-CHLORO-6-QUINAZOLINOL;4-chloro-6-hydroxy-quinazoline;4-chloro-6-oxy-quinazoline;6-QUINAZOLINOL,4-CHLORO;

Chemical Property of 4-CHLORO-6-HYDROXYQUINAZOLINE

Chemical Property:

• PSA: 46.01000
• LogP: 1.98880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Chloro-6-hydroxyquinazoline >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-HYDROXYQUINAZOLINE

There total 4 articles about 4-CHLORO-6-HYDROXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-chloroquinazoline-6-yl acetate (179246-11-8) → 4-chloroquinazolin-6-ol (848438-50-6)

Guidance literature:

With ammonia; In methanol; for 1h;

Reference yield: 68.0%

3,4-dihydro-4-oxoquinazolin-6-yl acetate (179688-15-4) → 4-chloroquinazolin-6-ol (848438-50-6)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; Reflux;

Reference yield:

6-hydroxyquinazolin-4(3H)-one (16064-10-1) → 4-chloroquinazolin-6-ol (848438-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 16 h / 100 °C

2: N,N-dimethyl-formamide; thionyl chloride / 2 h / Reflux

3: ammonia / methanol / 3 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; ammonia; N,N-dimethyl-formamide; In methanol;

DOI:10.1016/j.ejmech.2018.01.094

upstream raw materials:

4-chloroquinazoline-6-yl acetate

3,4-dihydro-4-oxoquinazolin-6-yl acetate

2-amino-5-hydroxybenzoic acid

6-hydroxyquinazolin-4(3H)-one

Downstream raw materials:

tert-butyl 4-[(4-chloroquinazolin-6-yl)oxy]piperidine-1-carboxylate

4-chloro-6-(butyrolactone-2-yloxy)-quinazoline

4-chloro-6-methoxyquinazoline

4-{[4-(benzyloxy)phenyl]amino}quinazolin-6-ol

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