Methanesulfonic acid, trifluoro-, 4-[[4-methoxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 4-[[4-methoxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenyl ester
CAS No.:848442-51-3
Molecular Formula:C20H23F3O4S
Molecular Weight:416.461
Hs Code.:

Synonyms:

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Chemical Property of Methanesulfonic acid, trifluoro-, 4-[[4-methoxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenyl ester

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Technology Process of Methanesulfonic acid, trifluoro-, 4-[[4-methoxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenyl ester

There total 7 articles about Methanesulfonic acid, trifluoro-, 4-[[4-methoxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

: 904925-60-6
4-(3-isopropyl-4-methoxy-benzyl)-3,5-dimethyl-phenol

: 358-23-6
trifluoromethylsulfonic anhydride

: 848442-51-3
3,5-dimethyl-4-(3'-isopropyl-4'-methoxybenzyl)phenyl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/ja003442j

Reference yield:

: 3,5-dimethyl-4-tert-butoxybenzaldehyde

: 848442-51-3
3,5-dimethyl-4-(3'-isopropyl-4'-methoxybenzyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert-butyllithium / tetrahydrofuran; pentane / 0.17 h / -78 - -20 °C

1.2: 86.2 percent / tetrahydrofuran; pentane / 2.5 h

2.1: 85.9 percent / AcOH; Pd-C; H₂ / ethanol / 12 h / 20 °C / 760.05 Torr

3.1: 92.9 percent / trifluoromethanesulfonic acid / 2,2,2-trifluoro-ethanol / 4 h / -4 °C

4.1: 80.4 percent / pyridine / 20 °C

With pyridine; palladium on activated charcoal; trifluorormethanesulfonic acid; hydrogen; tert.-butyl lithium; acetic acid; In tetrahydrofuran; ethanol; 2,2,2-trifluoroethanol; pentane;
DOI:10.1021/ja003442j

Reference yield:

: 2,6-dimethyl-4-tert-butoxyphenylbromide

: 848442-51-3
3,5-dimethyl-4-(3'-isopropyl-4'-methoxybenzyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert-butyllithium / tetrahydrofuran; pentane / 0.5 h / -78 - -20 °C

1.2: 92.4 percent / tetrahydrofuran; pentane / 2.5 h

2.1: tert-butyllithium / tetrahydrofuran; pentane / 0.17 h / -78 - -20 °C

2.2: 86.2 percent / tetrahydrofuran; pentane / 2.5 h

3.1: 85.9 percent / AcOH; Pd-C; H₂ / ethanol / 12 h / 20 °C / 760.05 Torr

4.1: 92.9 percent / trifluoromethanesulfonic acid / 2,2,2-trifluoro-ethanol / 4 h / -4 °C

5.1: 80.4 percent / pyridine / 20 °C

With pyridine; palladium on activated charcoal; trifluorormethanesulfonic acid; hydrogen; tert.-butyl lithium; acetic acid; In tetrahydrofuran; ethanol; 2,2,2-trifluoroethanol; pentane;
DOI:10.1021/ja003442j