Olanexidine

Base Information

Chemical Name:Olanexidine
CAS No.:146510-36-3
Molecular Formula:C₁₇H₂₇Cl₂N₅
Molecular Weight:372.341
Hs Code.:
UNII:92C2328G7P
DSSTox Substance ID:DTXSID601318290
Nikkaji Number:J918.107E
Wikidata:Q21099133
NCI Thesaurus Code:C90987
ChEMBL ID:CHEMBL1190262
Mol file:146510-36-3.mol

Synonyms:1-(3,4-dichlorobenzyl)-5-octylbiguanide;1-(3,4-dichlorobenzyl)-5-octylbiguanide, monohydrochloride;olanexidine;OPB-2045

Suppliers and Price of Olanexidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
OLANEXIDINE 95.00%
5MG
$ 503.79

Total 12 raw suppliers

Chemical Property of Olanexidine

Chemical Property:

Boiling Point:454.7±55.0 °C(Predicted)
PKA:11.92±0.10(Predicted)
Flash Point:258.2oC
PSA：83.79000
Density:1.22±0.1 g/cm3(Predicted)
LogP:5.86440
XLogP3:4.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:11
Exact Mass:371.1643513
Heavy Atom Count:24
Complexity:400

Purity/Quality:

99.90% ^*data from raw suppliers

OLANEXIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCN=C(N)NC(=NCC1=CC(=C(C=C1)Cl)Cl)N
Recent NIPH Clinical Trials:Effect of disinfectants on suture contamination in arthroscopic rotator cuff repair: a randomized controlled study
Description In July 2015, olanexidine gluconate, a biguanide compound with remarkable antibacterial activity, was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for skin antisepsis at surgical sites. The drug was developed and marketed by Otsuka Pharmaceutical in Japan and is available as topical solution (1.5%). Olanexidine gluconate exhibited efficacy against a wide range of bacterial strains, especially Grampositive bacteria. In vitro experiments exploring its mechanism of action indicated that olanexidine interacts with bacterial surface molecules (such as lipopolysaccharides and lipoteichoic acid), disrupting the cell membranes of liposomes. These models suggest that the drug permeates the membranes of both Escherichia coli and Staphylococcus aureus and denatures proteins at relatively high concentrations (>160 g/mL).

Technology Process of Olanexidine

There total 2 articles about Olanexidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 111-83-1
1-bromo-octane

: 116033-38-6
N¹-3,4-dichlorobenzyl biguanide

: 146510-36-3
N¹-(3,4-dichlorobenzyl)-N⁵-octyl biguanide

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In water; ethyl acetate; at 25 ℃; for 4h; Green chemistry;
DOI:10.1016/j.jics.2021.100150