CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER
• CAS No.: 848472-36-6
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.287
• Mol file: 848472-36-6.mol

Synonyms:N-Boc-2-amino-4,6-dimethylpyridine;2-(Boc-amino)-4,6-dimethylpyridine;(4,6-Dimethyl-2-pyridinyl)carbamic acid tert-butyl ester;tert-Butyl (4,6-dimethyl-2-pyridinyl)carbamate;(4,6-dimethyl-pyridin-2-yl)-carbamic acid tert-butyl ester;tert-butyl 4,6-dimethylpyridin-2-ylcarbamate;

Chemical Property of CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER

Chemical Property:

• Melting Point: 75-79°C
• PSA: 54.71000
• LogP: 3.05900

Purity/Quality:

98% ^*data from raw suppliers

2-(Boc-amino)-4,6-dimethylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER

There total 2 articles about CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-Amino-4,6-dimethylpyridine (5407-87-4) → tert-butyl (4,6-dimethylpyridin-2-yl)carbamate (848472-36-6)

Guidance literature:

In tert-butyl alcohol;

Reference yield: 85.0%

tert-butyldicarbonate (34619-03-9) + 2-Amino-4,6-dimethylpyridine (5407-87-4) → tert-butyl (4,6-dimethylpyridin-2-yl)carbamate (848472-36-6)

Guidance literature:

In tert-butyl alcohol;

DOI:10.1021/jm801220a

Reference yield: 42.0%

tert-butyl (4,6-dimethylpyridin-2-yl)carbamate (848472-36-6) + 3,5-bis(bromomethyl)benzonitrile (74163-48-7) → di-tert-butyl (((5-cyano-1,3-phenylene)bis-(ethane-2,1-diyl))bis(4-methylpyridine-6,2-diyl))dicarbamate

Guidance literature:

tert-butyl (4,6-dimethylpyridin-2-yl)carbamate; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

3,5-bis(bromomethyl)benzonitrile; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

DOI:10.1021/jm501723p

upstream raw materials:

di-tert-butyl dicarbonate

2-Amino-4,6-dimethylpyridine

tert-butyldicarbonate

Downstream raw materials:

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methyl-2-pyridyl)methyl)-4-(2-((2,2-difluoro-2-(3-fluorophenyl)ethyl)amino)ethoxy)pyrrolidine-1-carboxylate

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((2,2-difluoro-2-(3-chlorophenyl)ethyl)amino)ethoxy)pyrrolidine-1-carboxylate

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((2,2-difluoro-2-(2-chlorophenyl)ethyl)amino)ethoxy)pyrrolidine-1-carboxylate

C₃₆H₅₂F₂N₄O₇