3-(4-Hydroxyphenyl)-2-phenylpropanoic acid

Base Information

• Chemical Name: 3-(4-Hydroxyphenyl)-2-phenylpropanoic acid
• CAS No.: 89-23-6
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Hs Code.: 2918290000
• European Community (EC) Number: 201-888-4
• NSC Number: 60596
• DSSTox Substance ID: DTXSID001281520
• Nikkaji Number: J182.059A
• ChEMBL ID: CHEMBL82350
• Mol file: 89-23-6.mol

Synonyms:3-(4-hydroxyphenyl)-2-phenylpropanoic acid;89-23-6;3-(4-Hydroxyphenyl)-2-phenylpropionic acid;CHEMBL82350;3-(p-Hydroxyphenyl)-2-phenylpropionic acid;EINECS 201-888-4;NSC 60596;4-Hydroxy-alpha-phenylbenzenepropanoic acid;3-(4-Hydroxy-phenyl)-2-phenyl-propionic acid;Benzenepropanoic acid, 4-hydroxy-alpha-phenyl-;alpha-Phenyl-beta-p-hydroxyphenyl propionic acid;Propionic acid, 3-(p-hydroxyphenyl)-2-phenyl-;NSC60596;Benzenepropanoic acid,4-hydroxy-a-phenyl-;3-(4-Hydroxyphenyl)-2-phenylpropanoicacid;CBMicro_021130;Oprea1_100675;SCHEMBL5161421;DTXSID001281520;CCG-8822;BDBM50145814;MFCD00021710;NSC-60596;AKOS003239394;AKOS016844065;3-(4-hydroxyphenyl)-2-phenylpropionsyre;BS-35998;BIM-0021225.P001;3-(4-hydroxyphenyl)-2-phenyl-propanoic acid;VU0549296-1;EN300-235654;3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONICACID;Benzenepropanoic acid, 4-hydroxy-.alpha.-phenyl-;.alpha.-Phenyl-.beta.-p-hydroxyphenyl propionic acid;F9995-0115

Chemical Property of 3-(4-Hydroxyphenyl)-2-phenylpropanoic acid

Chemical Property:

• Vapor Pressure: 3.7E-07mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 210.6 °C
• PSA: 57.53000
• Density: 1.253g/cm³
• LogP: 2.80310
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Hydroxyphenyl)-2-phenylpropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CC2=CC=C(C=C2)O)C(=O)O

Technology Process of 3-(4-Hydroxyphenyl)-2-phenylpropanoic acid

There total 11 articles about 3-(4-Hydroxyphenyl)-2-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-hydroxyphenyl)-2-phenylacrylic acid (6962-09-0,51082-13-4) → 3-(4-hydroxyphenyl)-2-phenylpropanoic acid (89-23-6)

Guidance literature:

With sodium hydroxide; nickel; Hydrogenation;

Reference yield:

3-(4-methoxyphenyl)-2-phenylacrylic acid (6968-77-0,19319-32-5,13938-24-4) → 3-(4-hydroxyphenyl)-2-phenylpropanoic acid (89-23-6)

Guidance literature:

With nickel; at 100 ℃; under 44130.5 Torr; Hydrogenation_.anschliessendes Erhitzen mit wss. NaOH auf 220grad;

Reference yield:

phenylacetic acid (103-82-2) → 3-(4-hydroxyphenyl)-2-phenylpropanoic acid (89-23-6)

Guidance literature:

Multi-step reaction with 2 steps

2: nickel / 100 °C / 44130.5 Torr / Hydrogenation_.anschliessendes Erhitzen mit wss. NaOH auf 220grad

With nickel;

upstream raw materials:

3-(4-methoxyphenyl)-2-phenylacrylic acid

3-(4-methoxyphenyl)-2-phenylpropionic acid

(E)-3-(4-hydroxyphenyl)-2-phenylacrylic acid

3c-(4-hydroxy-phenyl)-2-phenyl-acrylic acid

Downstream raw materials:

3-(4-benzyloxy-phenyl)-2-phenyl-propionic acid

3-(4-hydroxy-phenyl)-2-phenylpropionic acid methyl ester

3-(4-benzyloxy-phenyl)-2-phenyl-propionic acid amide

1-phenyl-2-[4-(phenylmethoxy)phenyl]-ethylamine

Refernces