CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE
• CAS No.: 848497-98-3
• Molecular Formula: C5H11N.ClH
• Molecular Weight: 121.61
• Hs Code.: 2921300090
• Mol file: 848497-98-3.mol

Synonyms:N-methylcyclobutylamine hydrochloride;cyclobutyl-methylamine hydrochloride;N-methylcyclobutanamine hydrochloride;

Chemical Property of CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 1.95120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Methylcyclobutanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE

There total 2 articles about CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl cyclobutyl(methyl)carbamate (1180501-53-4) → N-methylcyclobutanamine hydrochloride (848497-98-3)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 4h;

DOI:10.1021/jm401603e

Reference yield:

N-cyclobutylformamide (87055-64-9) → N-methylcyclobutanamine hydrochloride (848497-98-3)

Guidance literature:

With hydrogenchloride; dimethylsulfide borane complex; Multistep reaction; 1.) THF, reflux, 14 h, 2.) THF, 80 deg C, 3 h;

DOI:10.1021/jm00047a006

Reference yield: 91.0%

(2R)-2-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]acetic acid (1228570-47-5) + N-methylcyclobutanamine hydrochloride (848497-98-3) → tert-butyl N-[(R)-(4-bromophenyl)[cyclobutyl(methyl)carbamoyl]methyl]carbamate

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

N-cyclobutylformamide

tert-butyl cyclobutyl(methyl)carbamate

Downstream raw materials:

(2S)-N-cyclobutyl-N-methyl-2-(tert-butoxycarbonylamino)-2-cyclohexylacetamide

(S)-[(N-cyclobutyl-N-methylcarbamoyl)-(4-oxocyclohexyl)methyl]carbamic acid tert-butyl ester

4-{(S)-4-carboxy-2-[(5-{2-[(S)-2-(cyclobutyl-methyl-carbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester