(E)-Ceftriaxone

Base Information

• Chemical Name: (E)-Ceftriaxone
• CAS No.: 92143-31-2
• Molecular Formula: C₁₈H₁₈N₈O₇S₃
• Molecular Weight: 554.588
• Mol file: 92143-31-2.mol

Synonyms:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,[6R-[6a,7b(E)]]-; Ro 15-2254

Chemical Property of (E)-Ceftriaxone

Chemical Property:

• PKA: 2.57±0.50(Predicted)
• PSA: 294.06000
• Density: 1.96±0.1 g/cm3(Predicted)
• LogP: -0.28900

Purity/Quality:

97% ^*data from raw suppliers

(E)-Ceftriaxone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The E-isomer of Ceftriaxone (C245000), a third-generation cephalosporin. The E-isomer of Ceftriaxone (C245000), a third-generation cephalosporin. An antibacterial.

Technology Process of (E)-Ceftriaxone

There total 17 articles about (E)-Ceftriaxone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

C18H14N5O9PS2 + 7-aminoceftrizine (58909-56-1) → ceftriaxone (73384-59-5,92143-31-2)

Guidance literature:

With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine; In ethanol; dichloromethane; at 0 - 5 ℃; for 4h;

DOI:10.1515/hc-2014-0048

Reference yield: 93.4%

C14H24N3O5PS2 + 7-aminoceftrizine (58909-56-1) → ceftriaxone (73384-59-5,92143-31-2)

Guidance literature:

With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine; In ethanol; dichloromethane; at 0 - 5 ℃; for 4h;

DOI:10.1515/hc-2014-0048

Reference yield: 93.3%

C18H14N5O10PS + 7-aminoceftrizine (58909-56-1) → ceftriaxone (73384-59-5,92143-31-2)

Guidance literature:

With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine; In ethanol; dichloromethane; at 0 - 5 ℃; for 4h;

DOI:10.1515/hc-2014-0048

upstream raw materials:

7-[4-bromo-2(Z)-methoxyimino-3-oxobutyramido]-3-[[2,5-(dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-3-cephem-4-carboxylic acid

thiourea

C₁₇H₁₇ClN₆O₈S₂

(6R,7R)-7-[2-[2-(2-chloroacetamido)-4-thiazolyl]-2-syn-methoxy-iminoacetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Downstream raw materials:

ceftriaxone disodium