Pyridine, 4-[4-[(1,1-dimethylethyl)thio]phenyl]-2,6-bis(iodomethyl)-

Base Information

Chemical Name:Pyridine, 4-[4-[(1,1-dimethylethyl)thio]phenyl]-2,6-bis(iodomethyl)-
CAS No.:848564-99-8
Molecular Formula:C17H19I2NS
Molecular Weight:523.22
Hs Code.:

Synonyms:

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Chemical Property of Pyridine, 4-[4-[(1,1-dimethylethyl)thio]phenyl]-2,6-bis(iodomethyl)-

Chemical Property:

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Technology Process of Pyridine, 4-[4-[(1,1-dimethylethyl)thio]phenyl]-2,6-bis(iodomethyl)-

There total 5 articles about Pyridine, 4-[4-[(1,1-dimethylethyl)thio]phenyl]-2,6-bis(iodomethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 848564-98-7
4-[4-tert-butylthio(phenyl)]-2,6-bis(chloromethyl)pyridine

: 848564-99-8
4-[4-tert-butylthio(phenyl)]-2,6-bis(iodomethyl)pyridine

Guidance literature:: With sodium iodide; In acetone; for 2h; Heating;
DOI:10.1016/j.tet.2004.12.020

Reference yield:

: 848564-95-4
4-chloro-2,6-bis(acetoxymethyl)pyridine

: 848564-99-8
4-[4-tert-butylthio(phenyl)]-2,6-bis(iodomethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / acetyl chloride; sodium iodide / acetonitrile / 18 h / 65 °C

2: 96 percent / sodium hydrogen carbonate; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; H₂O / 72 h / 50 °C

3: 96 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 14 h / Heating

4: 99 percent / sodium iodide / acetone / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; acetyl chloride; sodium iodide; In dichloromethane; water; acetone; toluene; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.tet.2004.12.020

Reference yield:

: 848564-96-5
4-iodo-2,6-bis(acetoxymethyl)pyridine

: 848564-99-8
4-[4-tert-butylthio(phenyl)]-2,6-bis(iodomethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / sodium hydrogen carbonate; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; H₂O / 72 h / 50 °C

2: 96 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 14 h / Heating

3: 99 percent / sodium iodide / acetone / 2 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; sodium iodide; In dichloromethane; water; acetone; toluene; 1: Suzuki coupling;
DOI:10.1016/j.tet.2004.12.020