Technology Process of Benzoic acid,
4-[[(2R)-2-(methoxymethoxy)-2-[(2R,2'R,5R,5'R)-octahydro-5'-[(1R,2Z)-
1-(methoxymethoxy)-2-undecenyl][2,2'-bifuran]-5-yl]ethoxy]methyl]-,
methyl ester
There total 9 articles about Benzoic acid,
4-[[(2R)-2-(methoxymethoxy)-2-[(2R,2'R,5R,5'R)-octahydro-5'-[(1R,2Z)-
1-(methoxymethoxy)-2-undecenyl][2,2'-bifuran]-5-yl]ethoxy]methyl]-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 18h;
DOI:10.1002/anie.200462264
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 69 percent / potassium hexamethyldisilazide / tetrahydrofuran / 5 h / -78 - 0 °C
2.1: 99 percent / second generation Grubbs catalyst / CH2Cl2 / 1 h / Heating
3.1: Ad-mix-α; MeSO2NH2; NaHCO3 / 2-methyl-propan-2-ol / 96 h / 0 °C
3.2: pyridine / 20 h / 0 - 20 °C
3.3: sodium methoxide / methanol / 44 h / 20 °C
4.1: 98 percent / DMSO; (COCl)2; NEt3 / CH2Cl2 / -78 - 20 °C
5.1: n-BuLi / tetrahydrofuran
5.2: tetrahydrofuran
6.1: trifluoroacetic acid / H2O / 20 °C
7.1: potassium carbonate / methanol / 3.5 h / Heating
8.1: 78 percent / ethyldiisopropylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 18 h / 0 - 20 °C
With
dmap; AD-mix-α; n-butyllithium; oxalyl dichloride; methanesulfonamide; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
3.1: Sharpless asymmetric dihydroxylation / 4.1: Swern oxidation / 7.1: Williamson cyclization;
DOI:10.1002/anie.200462264
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / 0 °C
2.1: 69 percent / potassium hexamethyldisilazide / tetrahydrofuran / 5 h / -78 - 0 °C
3.1: 99 percent / second generation Grubbs catalyst / CH2Cl2 / 1 h / Heating
4.1: Ad-mix-α; MeSO2NH2; NaHCO3 / 2-methyl-propan-2-ol / 96 h / 0 °C
4.2: pyridine / 20 h / 0 - 20 °C
4.3: sodium methoxide / methanol / 44 h / 20 °C
5.1: 98 percent / DMSO; (COCl)2; NEt3 / CH2Cl2 / -78 - 20 °C
6.1: n-BuLi / tetrahydrofuran
6.2: tetrahydrofuran
7.1: trifluoroacetic acid / H2O / 20 °C
8.1: potassium carbonate / methanol / 3.5 h / Heating
9.1: 78 percent / ethyldiisopropylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 18 h / 0 - 20 °C
With
dmap; AD-mix-α; n-butyllithium; oxalyl dichloride; methanesulfonamide; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
4.1: Sharpless asymmetric dihydroxylation / 5.1: Swern oxidation / 8.1: Williamson cyclization;
DOI:10.1002/anie.200462264
![4-{(R)-2-Hydroxy-2-[(2R,5R,2'R,5'R)-5'-((Z)-(R)-1-hydroxy-undec-2-enyl)-octahydro-[2,2']bifuranyl-5-yl]-ethoxymethyl}-benzoic acid methyl ester](/Databaselist/images/loading.webp)
