Technology Process of Benzonitrile,
4-[[6-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-9-[(4-methoxyphen
yl)methyl]-9H-purin-2-yl]amino]-
There total 4 articles about Benzonitrile,
4-[[6-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-9-[(4-methoxyphen
yl)methyl]-9H-purin-2-yl]amino]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / 1,2-dimethoxyethane / Heating
2: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 80 °C
With
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dimethoxyethane; toluene;
2: Buchwald-Hartwig coupling;
DOI:10.1080/00397911.2010.517615
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: potassium carbonate / 1,2-dimethoxyethane / Heating
3: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 80 °C
With
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;
3: Buchwald-Hartwig coupling;
DOI:10.1080/00397911.2010.517615
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: potassium carbonate / 1,2-dimethoxyethane / Heating
3: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 80 °C
With
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;
3: Buchwald-Hartwig coupling;
DOI:10.1080/00397911.2010.517615
