Technology Process of Urea,
N-(2,3-dihydro-2-oxo-1H-indol-4-yl)-N'-[[4-(trifluoromethyl)phenyl]methyl]
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There total 7 articles about Urea,
N-(2,3-dihydro-2-oxo-1H-indol-4-yl)-N'-[[4-(trifluoromethyl)phenyl]methyl]
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guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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In
ethyl acetate; N,N-dimethyl-formamide;
at 80 ℃;
for 8h;
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 100 °C
1.2: 3 h / 100 °C
2.1: toluene-4-sulfonic acid / acetic acid / 3 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr
4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux
5.1: ethyl acetate; N,N-dimethyl-formamide / 8 h / 80 °C
With
hydrogen; sodium hydride; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux
3: ethyl acetate; N,N-dimethyl-formamide / 8 h / 80 °C
With
hydrogen; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
ethanol; ethyl acetate; N,N-dimethyl-formamide;