Chemical Property of Mubritinib
Chemical Property:
- Vapor Pressure:2.43E-15mmHg at 25°C
- Melting Point:158.0 to 162.0 °C
- Refractive Index:1.577
- Boiling Point:620.897 °C at 760 mmHg
- PKA:1.45±0.10(Predicted)
- Flash Point:329.307 °C
- PSA：65.97000
- Density:1.258 g/cm3
- LogP:6.05720
- Storage Temp.:Store at +4°C
- XLogP3:5.4
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:10
- Exact Mass:468.17731048
- Heavy Atom Count:34
- Complexity:620
- Purity/Quality:
-
99%, *data from raw suppliers
TAK 165 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
- Isomeric SMILES:C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F
- Recent ClinicalTrials:Safety and Tolerability Study of TAK-165 in Subjects With Tumors Expressing HER2
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Uses
Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs
