Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]-

Base Information

Chemical Name:Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]-
CAS No.:848852-42-6
Molecular Formula:C31H47F3IN3O5Si2
Molecular Weight:781.802
Hs Code.:

Benzamide,
5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3-
[[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4-
iodophenyl)amino]-

Synonyms:

Suppliers and Price of Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]-

There total 5 articles about Benzamide, 5-[(E)-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]imino]methyl]-N-[3- [[(1,1-dimethylethyl)dimethylsilyl]oxy]propoxy]-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 848852-41-5
5-{[2-(tert-butyl-dimethyl-silanyloxy)-ethoxyimino]-methyl}-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

: 114778-46-0
3-<(tert-butyldimethylsilyl)oxy>propoxyamine

: 848852-42-6
5-{[2-(tert-butyl-dimethyl-silanyloxy)-ethoxyimino]-methyl}-N-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 203916-59-0
2,3,4-trifluoro-5-iodobenzoic acid

: 848852-42-6
5-{[2-(tert-butyl-dimethyl-silanyloxy)-ethoxyimino]-methyl}-N-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifuran-2-yl-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 3 h / 40 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.08 h / -78 °C

2.2: 72 h / 20 °C

2.3: pH 3

3.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 2 h / 20 °C

4.1: dichloromethane / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium periodate; osmium(VIII) oxide; trifuran-2-yl-phosphane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water;

Reference yield:

: 848852-32-4
2,3,4-trifluoro-5-vinylbenzoic acid

: 848852-42-6
5-{[2-(tert-butyl-dimethyl-silanyloxy)-ethoxyimino]-methyl}-N-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.08 h / -78 °C

1.2: 72 h / 20 °C

1.3: pH 3

2.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 2 h / 20 °C

3.1: dichloromethane / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sodium periodate; osmium(VIII) oxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water;