5-Chloropyrazine-2-carboxylic acid hydrazide

Base Information

• Chemical Name: 5-Chloropyrazine-2-carboxylic acid hydrazide
• CAS No.: 848952-83-0
• Molecular Formula: C5H5ClN4O
• Molecular Weight: 172.57200
• Hs Code.: 2933990090
• Mol file: 848952-83-0.mol

Synonyms:5-chloro-2-pyrazinecarbohydrazide;5-chloroprazine-2-carboxylic acid hydrazide;methyl 5-chloropyrazine-2-carboxylic;5-Chloropyrazine-2-carboxylic acid hydrazide;QC-6813;

Chemical Property of 5-Chloropyrazine-2-carboxylic acid hydrazide

Chemical Property:

• PKA: 9.51±0.10(Predicted)
• PSA: 80.90000
• Density: 1.496g/cm3
• LogP: 0.82470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloropyrazine-2-carboxylicacidhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloropyrazine-2-carboxylic acid hydrazide

There total 5 articles about 5-Chloropyrazine-2-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → 5-chloro-pyrazine-2-carboxylic acid hydrazide (848952-83-0)

Guidance literature:

With hydrazine hydrate; In methanol; water; at 0 ℃; for 16h;

DOI:10.1021/acs.jmedchem.5b00678

Reference yield: 50.0%

→ 5-chloro-pyrazine-2-carboxylic acid hydrazide (848952-83-0)

Guidance literature:

Reference yield:

ethyl 5-chloro-2-pyrazinecarboxylate (54013-04-6) → 5-chloro-pyrazine-2-carboxylic acid hydrazide (848952-83-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 4h; Reflux;

DOI:10.2174/1570180815666180816124102

upstream raw materials:

methyl 5-chloropyrazine-2-carboxylate

1,1-dimethylethyl 2-[(5-chloro-2-pyrazinyl)carbonyl]hydrazinecarboxylate

5-chloropyrazinoic acid

ethyl 5-chloro-2-pyrazinecarboxylate

Downstream raw materials:

2-chloro-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-pyrazine