2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid, 5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl ester, (5S,6E,11E,13S)-

Base Information

Chemical Name:2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid, 5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl ester, (5S,6E,11E,13S)-
CAS No.:848983-65-3
Molecular Formula:C37H47N3O4
Molecular Weight:597.798
Hs Code.:

2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid,
5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl
ester, (5S,6E,11E,13S)-

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Chemical Property of 2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid, 5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl ester, (5S,6E,11E,13S)-

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Technology Process of 2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid, 5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl ester, (5S,6E,11E,13S)-

There total 5 articles about 2-Oxa-4,9,14-triazapentadeca-6,11-dien-15-oic acid, 5,13-bis(1-methylethyl)-3-oxo-1-phenyl-9-(phenylmethyl)-, phenylmethyl ester, (5S,6E,11E,13S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 848983-62-0
((E)-(S)-4-Bromo-1-isopropyl-but-2-enyl)-carbamic acid benzyl ester

: 100-46-9
benzylamine

: 848983-65-3
{(E)-(S)-4-[Benzyl-((E)-(S)-4-benzyloxycarbonylamino-5-methyl-hex-2-enyl)-amino]-1-isopropyl-but-2-enyl}-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1016/j.tetasy.2004.12.013

Reference yield:

: 848983-59-5
((E)-(S)-4-Hydroxy-1-isopropyl-but-2-enyl)-carbamic acid benzyl ester

: 848983-65-3
{(E)-(S)-4-[Benzyl-((E)-(S)-4-benzyloxycarbonylamino-5-methyl-hex-2-enyl)-amino]-1-isopropyl-but-2-enyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 5 h / 20 °C

2: 91 percent / potassium carbonate / dimethylformamide / 13 h / 20 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2004.12.013

Reference yield:

: 848983-56-2
(E)-(S)-4-Benzyloxycarbonylamino-5-methyl-hex-2-enoic acid ethyl ester

: 848983-65-3
{(E)-(S)-4-[Benzyl-((E)-(S)-4-benzyloxycarbonylamino-5-methyl-hex-2-enyl)-amino]-1-isopropyl-but-2-enyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / BF₃*Et₂O; DIBAL / hexane; CH₂Cl₂ / 1.5 h / -78 °C

2: 77 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 5 h / 20 °C

3: 91 percent / potassium carbonate / dimethylformamide / 13 h / 20 °C

With carbon tetrabromide; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2004.12.013