Cyclohexanol, 2-azido-2-methyl-5-(1-methylethenyl)-, (1R,2R,5S)-

Base Information

• Chemical Name: Cyclohexanol, 2-azido-2-methyl-5-(1-methylethenyl)-, (1R,2R,5S)-
• CAS No.: 849065-24-3
• Molecular Formula: C10H17N3O
• Molecular Weight: 195.264
• Mol file: 849065-24-3.mol

Synonyms:

Chemical Property of Cyclohexanol, 2-azido-2-methyl-5-(1-methylethenyl)-, (1R,2R,5S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanol, 2-azido-2-methyl-5-(1-methylethenyl)-, (1R,2R,5S)-

There total 1 articles about Cyclohexanol, 2-azido-2-methyl-5-(1-methylethenyl)-, (1R,2R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(-)-limonene oxide (203719-53-3) → (1R,2R,5S)-2-azido-2-methyl-5-(prop-1-en-2-yl)cyclohexanol (849065-24-3) + (1R,2R,4S)-2-azido-1-methyl-4-(prop-1-en-2-yl)cyclohexanol

Guidance literature:

With sodium azide; ammonium chloride; In methanol; for 32h; regioselective reaction; Reflux;

DOI:10.1016/j.tetasy.2009.08.012

Reference yield: 86.0%

(1R,2R,5S)-2-azido-2-methyl-5-(prop-1-en-2-yl)cyclohexanol (849065-24-3) → (1R,2R,5S)-2-amino-2-methyl-5-(prop-1-en-2-yl)cyclohexanol (1202006-44-7)

Guidance literature:

(1R,2R,5S)-2-azido-2-methyl-5-(prop-1-en-2-yl)cyclohexanol; With lithium aluminium tetrahydride; In tert-butyl methyl ether; at 0 - 20 ℃; for 1h;

With water; sodium sulfate; In tert-butyl methyl ether;

DOI:10.1016/j.tetasy.2009.08.012

upstream raw materials:

(-)-limonene oxide

Downstream raw materials:

(1R,2R,5S)-2-amino-2-methyl-5-(prop-1-en-2-yl)cyclohexanol