Technology Process of 1-Pyrrolidinecarboxylic acid,
2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-,
1,1-dimethylethyl ester, (2R,3S)-
There total 4 articles about 1-Pyrrolidinecarboxylic acid,
2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-,
1,1-dimethylethyl ester, (2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3S)-2-Allyl-3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid tert-butyl ester;
With
dimethylsulfide borane complex;
In
hexane;
at 25 - 30 ℃;
for 12h;
With
sodium hydroxide; dihydrogen peroxide;
In
ethanol; hexane;
DOI:10.1055/s-2004-837194
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 68 percent / p-TsOH*H2O; PPTS / CH2Cl2 / 30 h / 20 °C
2.1: n-BuLi; lithium naphthalenide / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 57 percent / tetrahydrofuran; hexane / 1 h / -78 °C
3.1: BH3*SMe2 / hexane / 12 h / 25 - 30 °C
3.2: 50 percent / aq. NaOH; H2O2 / hexane; ethanol
With
n-butyllithium; dimethylsulfide borane complex; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; naphthalen-1-yl-lithium;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2004-837194
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi; lithium naphthalenide / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 57 percent / tetrahydrofuran; hexane / 1 h / -78 °C
2.1: BH3*SMe2 / hexane / 12 h / 25 - 30 °C
2.2: 50 percent / aq. NaOH; H2O2 / hexane; ethanol
With
n-butyllithium; dimethylsulfide borane complex; naphthalen-1-yl-lithium;
In
tetrahydrofuran; hexane;
DOI:10.1055/s-2004-837194