3-Cyclohexene-1-acetonitrile, 2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)- 4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)-

Base Information

Chemical Name:3-Cyclohexene-1-acetonitrile, 2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)- 4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)-
CAS No.:849122-92-5
Molecular Formula:C35H49NO3Si
Molecular Weight:559.864
Hs Code.:

3-Cyclohexene-1-acetonitrile,
2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)-
4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Cyclohexene-1-acetonitrile, 2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)- 4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)-

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Technology Process of 3-Cyclohexene-1-acetonitrile, 2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)- 4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)-

There total 7 articles about 3-Cyclohexene-1-acetonitrile, 2-[(2S,3S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-(methoxymethoxy)- 4-pentenyl]-3-methyl-6-(1-methylethyl)-, (1R,2R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 849122-91-4
Methanesulfonic acid (1R,2R,6R)-2-[(2S,3S)-2-(tert-butyl-diphenyl-silanyloxy)-3-methoxymethoxy-pent-4-enyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

: 151-50-8
potassium cyanide

: 849122-92-5
{(1R,2R,6R)-2-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-pent-4-enyl]-6-isopropyl-3-methyl-cyclohex-3-enyl}-acetonitrile

Guidance literature:: With 18-crown-6 ether; In acetonitrile; at 80 ℃; for 6h;
DOI:10.1016/j.tet.2004.12.039

Reference yield:

: 849122-77-6
(2S,3S)-1-((1R,5R,6R)-6-Dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-3-methoxymethoxy-pent-4-en-2-ol

: 849122-92-5
{(1R,2R,6R)-2-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-pent-4-enyl]-6-isopropyl-3-methyl-cyclohex-3-enyl}-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / imidazole / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 100 percent / AcOH / tetrahydrofuran; H₂O / 15 h / 20 °C

3: 71 percent / NaBH₄ / ethanol / 0.33 h / 20 °C

4: 98 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

5: 91 percent / 18-crown-6 / acetonitrile / 6 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; 18-crown-6 ether; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2004.12.039

Reference yield:

: (1R,2R,6R)-2-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-pent-4-enyl]-6-isopropyl-3-methyl-cyclohex-3-enecarbaldehyde

: 849122-92-5
{(1R,2R,6R)-2-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-pent-4-enyl]-6-isopropyl-3-methyl-cyclohex-3-enyl}-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NaBH₄ / ethanol / 0.33 h / 20 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 91 percent / 18-crown-6 / acetonitrile / 6 h / 80 °C

With sodium tetrahydroborate; 18-crown-6 ether; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2004.12.039