3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione

Base Information

Chemical Name:3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione
CAS No.:91897-61-9
Molecular Formula:C₂₂H₂₃NO₆
Molecular Weight:397.428
Hs Code.:

Synonyms:3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione;Isoquino(1,2-b)(3)benzazepine-6,14-dione,5,8,9,14a-tetrahydro-3,4,11,12-tetramethoxy;Saulatine;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione

Chemical Property:

Vapor Pressure:8.21E-16mmHg at 25°C
Boiling Point:630.6°Cat760mmHg
Flash Point:335.2°C
PSA：74.30000
Density:1.33g/cm³
LogP:2.52370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione

There total 10 articles about 3,4,11,12-tetramethoxy-5,8,9,14a-tetrahydroisoquino[1,2-b][3]benzazepine-6,14-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 154535-11-2
5,6-dimethoxy-2-(3,4-dimethoxyphenyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-1-carboxylic acid

: 91897-61-9
saulatine

Guidance literature:: With PPA; for 7h;
DOI:10.1002/jhet.5570300541

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 91897-61-9
saulatine

Guidance literature:: Multi-step reaction with 9 steps

1: MgSO₄ / diethyl ether / Ambient temperature

2: PhNEt₂ / toluene / Heating

3: 66 percent / Bu₃SnH, azo(cyclohexanecarbonitrile) / toluene / Heating

4: MCPBA / CH₂Cl₂ / -20 °C

5: TFAA / CH₂Cl₂ / Ambient temperature

6: MCPBA / CH₂Cl₂ / -20 °C

7: CH₂Cl₂ / Ambient temperature

8: 56 percent / K₂CO₃ / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

9: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) -78 deg C to r.t., 2 h

With oxalyl dichloride; tri-n-butyl-tin hydride; magnesium sulfate; potassium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; trifluoroacetic anhydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In methanol; diethyl ether; dichloromethane; toluene;

Reference yield:

: 1026853-30-4
(2,2-Bis-phenylsulfanyl-vinyl)-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

: 91897-61-9
saulatine

Guidance literature:: Multi-step reaction with 8 steps

1: PhNEt₂ / toluene / Heating

2: 66 percent / Bu₃SnH, azo(cyclohexanecarbonitrile) / toluene / Heating

3: MCPBA / CH₂Cl₂ / -20 °C

4: TFAA / CH₂Cl₂ / Ambient temperature

5: MCPBA / CH₂Cl₂ / -20 °C

6: CH₂Cl₂ / Ambient temperature

7: 56 percent / K₂CO₃ / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

8: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) -78 deg C to r.t., 2 h

With oxalyl dichloride; tri-n-butyl-tin hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; trifluoroacetic anhydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In methanol; dichloromethane; toluene;