1-Oxo-7-Boc-7-azaspiro[3....

Base Information

• Chemical Name: 1-Oxo-7-Boc-7-azaspiro[3....
• CAS No.: 849203-60-7
• Molecular Formula: C13H21NO3
• Molecular Weight: 239.315
• Hs Code.: 2933990090
• Mol file: 849203-60-7.mol

Synonyms:3-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester;1-Oxo-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester;tert-butyl 1-oxo-7-azaspiro[3.5]nonane-7-carboxylate;1-Oxo-7-Boc-7-azaspiro[3.5]nonane;N-BOC-1-OXO-7-AZASPIRO[3.5]NONANE;

Chemical Property of 1-Oxo-7-Boc-7-azaspiro[3....

Chemical Property:

• Boiling Point: 348.6±35.0 °C(Predicted)
• PKA: -0.82±0.20(Predicted)
• PSA: 46.61000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.30450
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

3-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxo-7-Boc-7-azaspiro[3....

There total 5 articles about 1-Oxo-7-Boc-7-azaspiro[3.... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + cyclopropyldiphenylsulfonium triflate (116808-70-9) → tert-butyl-1-oxo-7-azaspiro[3.5]-nonane-7-carboxylate (849203-60-7)

Guidance literature:

cyclopropyldiphenylsulfonium triflate; With potassium hexamethylsilazane; In tetrahydrofuran; at -40 ℃; for 0.0833333h;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at -40 - 20 ℃; for 3.33333h;

With lithium tetrafluoroborate; In toluene; at 80 ℃; for 2h;

Reference yield:

tert-butyl 10-oxa-7-azadispiro[2.0.5.1]decane-7-carboxylate (849203-59-4) → tert-butyl-1-oxo-7-azaspiro[3.5]-nonane-7-carboxylate (849203-60-7)

Guidance literature:

With lithium tetrafluoroborate; In toluene; at 80 ℃; for 1.5h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + cyclopropyldiphenylsulfonium tetrafluoroborate (33462-81-6) → tert-butyl-1-oxo-7-azaspiro[3.5]-nonane-7-carboxylate (849203-60-7)

Guidance literature:

cyclopropyldiphenylsulfonium tetrafluoroborate; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at 20 ℃; for 1h;

With silica gel; In dichloromethane; at 40 ℃; for 3h;

upstream raw materials:

tert-butyl 10-oxa-7-azadispiro[2.0.5.1]decane-7-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

cyclopropyldiphenylsulfonium triflate

cyclopropyldiphenylsulfonium tetrafluoroborate

Downstream raw materials:

1-hydroxy-7-azaspiro[1-3]nonan-7-tert-butyl carboxylate

tert-butyl 1-(benzylamino)-7-azaspiro[3.5 ]nonane-7-carboxylate

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